Humanized mice for the study of type 1 and type 2 diabetes.

Authors

D L. Greiner
M A. Brehm
V Hosur
D M. Harlan
A C. Powers
L D. ShultzFollow

Document Type

Article

Publication Date

2011

Keywords

Diabetes-Mellitus-Type-1, Diabetes-Mellitus-Type-2, Disease-Models-Animal, HLA-Antigens, Hematopoietic-Stem-Cell-Transplantation, Humans, Hyperglycemia, Interleukin-Receptor-Common-gamma-Subunit, Islets-of-Langerhans-Transplantation, Mice-Inbred-NOD, Mice-SCID, Mice-Transgenic, Transplantation-Heterologous

JAX Source

Ann N Y Acad Sci 2011 Dec; 1245:55-8.

First Page

55

Last Page

58

Abstract

The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk.

Recommended Citation

Greiner DL, Brehm MA, Hosur V, Harlan DM, Powers AC, Shultz LD. Humanized mice for the study of type 1 and type 2 diabetes. Ann N Y Acad Sci 2011 Dec; 1245:55-8.