GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.
Document Type
Article
Publication Date
4-1-2011
Keywords
Chromosomes, Human, Pair 6, Denmark, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Genome-Wide Association Study, Haplotypes, Histocompatibility Antigens Class II, Humans, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Polymorphism, Single Nucleotide, Risk Factors, Sweden
JAX Source
PLoS Genet 2011 Apr; 7(4):e1001378.
PMID
21533074
Volume
7
Issue
4
First Page
1001378
Last Page
1001378
ISSN
1553-7404
Abstract
Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL-associated locus on 6p21.32, rs2647012 (OR(combined) = 0.64, P(combined) = 2 × 10(-21)) located 962 bp away from rs10484561 (r(2)
Recommended Citation
Smedby K,
Foo J,
Skibola C,
Darabi H,
Conde L,
Hjalgrim H,
Kumar V,
Chang E,
Rothman N,
Cerhan J,
Brooks-Wilson A,
Rehnberg E,
Irwan I,
Ryder L,
Brown P,
Bracci P,
Agana L,
Riby J,
Cozen W,
Davis S,
Hartge P,
Morton L,
Severson R,
Wang S,
Slager S,
Fredericksen Z,
Novak A,
Kay N,
Habermann T,
Armstrong B,
Kricker A,
Milliken S,
Purdue M,
Vajdic C,
Boyle P,
Lan Q,
Zahm S,
Zhang Y,
Zheng T,
Leach S,
Spinelli J,
Smith M,
Chanock S,
Padyukov L,
Alfredsson L,
Klareskog L,
Glimelius B,
Melbye M,
Liu E,
Adami H,
Humphreys K,
Liu J.
GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma. PLoS Genet 2011 Apr; 7(4):e1001378.