Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.
Document Type
Article
Publication Date
2011
Keywords
Antigen-Presenting-Cells, Diabetes-Mellitus-Type-1, Disease-Models-Animal, Mice-Inbred-NOD, T-Lymphocytes
JAX Source
Semin Immunopathol 2011 Jan; 33(1):67-87.
First Page
67
Last Page
87
Abstract
For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type 1 diabetes (T1D). However, while sharing many similarities, it is becoming increasingly appreciated that there are also some differences in the immunopathogenic basis of T1D development between humans and NOD mice. This review will focus on aspects of T1D development in NOD mice that are similar and different from that in humans.
Recommended Citation
Driver JP,
Serreze DV,
Chen YG.
Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol 2011 Jan; 33(1):67-87.