Mouse resources for craniofacial research.
Document Type
Article
Publication Date
2011
Keywords
Craniofacial-Abnormalities, Databases-Factual, Integrases, International-Cooperation, Internet, Maxillofacial-Development, Mice-Mutant-Strains, Models-Animal, Mutation, Phenotype, Skull
JAX Source
Genesis 2011 Apr; 49(4):190-9.
First Page
190
Last Page
199
Abstract
The mouse, as a genetically defined and easily manipulated model organism, has played a critical role in unraveling the mechanisms of craniofacial development and dysmorphology. While numerous gene knockout strains that display craniofacial abnormalities and essential recombinase tool strains with craniofacial-specific expression have been generated, many are absent from public repositories. Large-scale, international resource-generating initiatives promise to address this concern, providing a comprehensive set of targeted mutations and a suite of new Cre driver strains. In addition, panels of genetically defined strains provide tools to dissect the multigenic, complex nature of craniofacial development, adding to the foundation of information gained from single gene studies. Continued progress will require awareness and access to these essential mouse resources. In this review, current mouse resources, large-scale efforts, and potential future directions will be outlined and discussed.
Recommended Citation
Murray SA.
Mouse resources for craniofacial research. Genesis 2011 Apr; 49(4):190-9.