Mouse mutants and phenotypes: accessing information for the study of mammalian gene function.
Document Type
Article
Publication Date
2011
Keywords
Cell-Line, Databases-Genetic, Disease-Models-Animal, Embryonic-Stem-Cells, Genes, Genetic-Diseases-Inborn, Humans, Mice-Mutant-Strains, Mutation, Online-Systems, Organ-Specificity, Phenotype, Promoter-Regions-Genetic, Recombinases
JAX Source
Methods 2011 Apr; 53(4):405-10.
First Page
405
Last Page
410
Abstract
Recent advances in high-throughput gene targeting and conditional mutagenesis are creating new and powerful resources to study the in vivo function of mammalian genes using the mouse as an experimental model. Mutant ES cells and mice are being generated at a rapid rate to study the molecular and phenotypic consequences of genetic mutations, and to correlate these study results with human disease conditions. Likewise, classical genetics approaches to identify mutations in the mouse genome that cause specific phenotypes have become more effective. Here, we describe methods to quickly obtain information on what mutant ES cells and mice are available, including recombinase driver lines for the generation of conditional mutants. Further, we describe means to access genetic and phenotypic data that identify mouse models for specific human diseases.
Recommended Citation
Ringwald M,
Eppig JT.
Mouse mutants and phenotypes: accessing information for the study of mammalian gene function. Methods 2011 Apr; 53(4):405-10.