The mammalian gene function resource: the international knockout mouse consortium.
Document Type
Article
Publication Date
10-1-2012
JAX Source
Mamm Genome 2012 Oct; 23:580-586.
PMID
22968824
Volume
23
Issue
9-10
First Page
580
Last Page
586
ISSN
1432-1777
Abstract
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal ( www.knockoutmouse.org ) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
Recommended Citation
Bradley A,
Anastassiadis K,
Ayadi A,
Battey J,
Bell C,
Birling M,
Bottomley J,
Brown S,
Bürger A,
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Finnell R,
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Friedel R,
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Hicks G,
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Marschall S,
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Moore M,
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Nagy A,
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The mammalian gene function resource: the international knockout mouse consortium. Mamm Genome 2012 Oct; 23:580-586.