Proteotoxic stress of cancer: implication of the heat-shock response in oncogenesis.
Document Type
Article
Publication Date
8-2012
Keywords
Cell Transformation, Neoplastic, Cytoprotection, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Heat-Shock Response, Humans, Neoplasms, Oxidative Stress, Reactive Oxygen Species, Transcription Factors
JAX Source
J Cell Physiol 2012 Aug; 227(8):2982-7.
PMID
22105155
Volume
227
Issue
8
First Page
2982
Last Page
2987
ISSN
1097-4652
Abstract
Organisms frequently encounter a wide variety of proteotoxic stressors. The heat-shock response, an ancient cytoprotective mechanism, has evolved to augment organismal survival and longevity in the face of proteotoxic stress from without and within. These broadly recognized beneficial effects, ironically, contrast sharply with its emerging role as a culprit in the pathogenesis of cancers. Here, we present an overview of the normal biology of the heat-shock response and highlight its implications in oncogenic processes, including the proteotoxic stress phenotype of cancer; the function of this stress response in helping cancer survive and adapt to proteotoxic stress; and perturbation of proteome homeostasis in cancer as a potential therapeutic avenue.
Recommended Citation
Dai C,
Dai S,
Cao J.
Proteotoxic stress of cancer: implication of the heat-shock response in oncogenesis. J Cell Physiol 2012 Aug; 227(8):2982-7.