EMAP/EMAPA ontology of mouse developmental anatomy: 2013 update.
Document Type
Article
Publication Date
8-26-2013
Volume
4
Issue
1
First Page
15
Last Page
15
ISSN
2041-1480
PMID
23972281
Sponsor
J Biomed Semantics. 2013 Aug 26;4(1):15.
Abstract
BACKGROUND: The Edinburgh Mouse Atlas Project (EMAP) ontology of mouse developmental anatomy provides a standard nomenclature for describing normal and mutant mouse embryo anatomy. The ontology forms the core of the EMAP atlas and is used for annotating gene expression data by the mouse Gene Expression Database (GXD), Edinburgh Mouse Atlas of Gene Expression (EMAGE) and other database resources. J Biomed Semantics. 2013 Aug 26;4(1):15.
FINDINGS: The original EMAP ontology listed anatomical entities for each developmental stage separately, presented as uniparental graphs organized as a strict partonomy. An ``abstract'' (i.e. non-stage-specific) representation of mouse developmental anatomy has since been developed. In this version (EMAPA) all instances for a given anatomical entity are presented as a single term, together with the first and last stage at which it is considered to be present. Timed-component anatomies are now derived using staging information in the ``primary'' non-timed version. Anatomical entities are presented as a directed acyclic graph enabling multiple parental relationships. Subsumption classification as well as partonomic and other types of relationships can now be represented. Most concept names are unique, with compound names constructed using standardized nomenclature conventions, and alternative names associated as synonyms.
CONCLUSIONS: The ontology has been extended and refined in a collaborative effort between EMAP and GXD, with additional input from others. Efforts are also underway to improve the revision process with regards to updating and editorial control. The revised EMAPA ontology is freely available from the OBO Foundry resource, with descriptive information and other documentation presented in associatedWiki pages (www.obofoundry.org/wiki/index.php/EMAPA:Main_Page).
Recommended Citation
Hayamizu TF,
Wicks M,
Davidson D,
Burger A,
Ringwald M,
Baldock R.
EMAP/EMAPA ontology of mouse developmental anatomy: 2013 update. . 2013; 4(1):15