IL-21 Is a Double-Edged Sword in the Systemic Lupus Erythematosus-like Disease of BXSB.Yaa Mice.

Authors

Caroline G. McPhee, The Jackson LaboratoryFollow
Jason A. Bubier, The Jackson LaboratoryFollow
Thomas J. Sproule, The Jackson LaboratoryFollow
Giljun Park, The Jackson LaboratoryFollow
Martin P Steinbuck
William H. Schott, The Jackson LaboratoryFollow
Gregory J. Christianson, The Jackson LaboratoryFollow
Herbert C Morse
Derry C. Roopenian, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

11-1-2013

JAX Source

J Immunol 2013 Nov 1; 191(9):4581-8.

Volume

191

Issue

9

First Page

4581

Last Page

4588

ISSN

1550-6606

PMID

24078696

Abstract

The pleiotropic cytokine IL-21 is implicated in the pathogenesis of human systemic lupus erythematosus by polymorphisms in the molecule and its receptor (IL-21R). The systemic lupus erythematosus-like autoimmune disease of BXSB.Yaa mice is critically dependent on IL-21 signaling, providing a model for understanding IL-21/IL-21R signaling in lupus pathogenesis. In this study, we generated BXSB.Yaa mice selectively deficient in IL-21R on B cells, on all T cells, or on CD8(+) T cells alone and examined the effects on disease. We found that IL-21 signaling to B cells is essential for the development of all classical disease manifestations, but that IL-21 signaling also supports the expansion of central memory, CD8(+) suppressor cells and broadly represses the cytokine activity of CD4(+) T cells. These results indicate that IL-21 has both disease-promoting and disease-suppressive effects in the autoimmune disease of BXSB.Yaa mice. J Immunol 2013 Nov 1; 191(9):4581-8.

Recommended Citation

McPhee CG, Bubier JA, Sproule TJ, Park G, Steinbuck M, Schott WH, Christianson GJ, Morse H, Roopenian DC. IL-21 Is a Double-Edged Sword in the Systemic Lupus Erythematosus-like Disease of BXSB.Yaa Mice. J Immunol 2013 Nov 1; 191(9):4581-8.