STAT3 targets suggest mechanisms of aggressive tumorigenesis in diffuse large B-cell lymphoma.
Document Type
Article
Publication Date
12-9-2013
JAX Source
G3 (Bethesda) 2013 Dec 9; 3(12):2173-85.
Volume
3
Issue
12
First Page
2173
Last Page
2185
ISSN
2160-1836
PMID
24142927
Abstract
The signal transducer and activator of transcription 3 (STAT3) is a transcription factor that, when dysregulated, becomes a powerful oncogene found in many human cancers, including diffuse large B-cell lymphoma. Diffuse large B-cell lymphoma is the most common form of non-Hodgkin's lymphoma and has two major subtypes: germinal center B-cell-like and activated B-cell-like. Compared with the germinal center B-cell-like form, activated B-cell-like lymphomas respond much more poorly to current therapies and often exhibit overexpression or overactivation of STAT3. To investigate how STAT3 might contribute to this aggressive phenotype, we have integrated genome-wide studies of STAT3 DNA binding using chromatin immunoprecipitation-sequencing with whole-transcriptome profiling using RNA-sequencing. STAT3 binding sites are present near almost a third of all genes that differ in expression between the two subtypes, and examination of the affected genes identified previously undetected and clinically significant pathways downstream of STAT3 that drive oncogenesis. Novel treatments aimed at these pathways may increase the survivability of activated B-cell-like diffuse large B-cell lymphoma. G3 (Bethesda) 2013 Dec 9; 3(12):2173-85.
Recommended Citation
Hardee J,
Ouyang Z,
Zhang Y,
Kundaje A,
Lacroute P,
Snyder M.
STAT3 targets suggest mechanisms of aggressive tumorigenesis in diffuse large B-cell lymphoma. G3 (Bethesda) 2013 Dec 9; 3(12):2173-85.