Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain.

Document Type

Article

Publication Date

1-1-2013

Keywords

Aging, Animals, Animals, Wild, Body Temperature Regulation, Body Weight, Female, Gene Expression Regulation, Humans, Longevity, Male, Mice, Mice, Inbred C57BL, Micronesia, Quantitative Trait Loci

JAX Source

J Gerontol A Biol Sci Med Sci 2013; 68(1):27-34.

Volume

68

Issue

1

First Page

27

Last Page

35

ISSN

1758-535X

PMID

22570136

Abstract

Quantitative trait loci (QTL) of longevity identified in human and mouse are significantly colocalized, suggesting that common mechanisms are involved. However, the limited number of strains that have been used in mouse longevity studies undermines the ability to identify longevity genes. We crossed C57BL/6J mice with a new wild-derived strain, Pohn, and identified two life span QTL-Ls1 and Ls2. Interestingly, homologous human longevity QTL colocalize with Ls1. We also defined new QTL for metabolic heat production and body weight. Both phenotypes are significantly correlated with life span. We found that large clone ratio, an in vitro indicator for cellular senescence, is not correlated with life span, suggesting that cell senescence and intrinsic aging are not always associated. Overall, by using Pohn mice, we identified new QTL for longevity-related traits, thus facilitating the exploration of the genetic regulation of aging. J Gerontol A Biol Sci Med Sci 2013; 68(1):27-34.

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