Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.
Document Type
Article
Publication Date
1-2013
Keywords
Age Factors, Aging, Animals, Body Weight, Curcumin, Drug Evaluation, Preclinical, Female, Longevity, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Models, Animal, Motor Activity, Oxaloacetic Acid, Pregnancy, Sex Characteristics, Stilbenes, Tea, Triglycerides
JAX Source
J Gerontol A Biol Sci Med Sci 2013; 68(1):6-16.
Volume
68
Issue
1
First Page
6
Last Page
16
ISSN
1758-535X
PMID
22451473
Abstract
The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is the goal of the ITP to publish all results, negative or positive. We report here on the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin, oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of genetically heterogeneous mice. Each agent was administered beginning at 4 months of age. None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the risk of midlife deaths in females only. J Gerontol A Biol Sci Med Sci 2013; 68(1):6-16.
Recommended Citation
Strong R,
Miller R,
Astle CM,
Baur J,
de Cabo R,
Fernandez E,
Guo W,
Javors M,
Kirkland J,
Nelson J,
Sinclair D,
Teter B,
Williams D,
Zaveri N,
Nadon N,
Harrison DE.
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2013; 68(1):6-16.