Humanized mice for the study of infectious diseases.
Document Type
Article
Publication Date
8-2013
JAX Source
Curr Opin Immunol 2013 Aug; 25(4):428-35.
ISSN
1879-0372
PMID
23751490
Abstract
Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to prevent and treat human infectious diseases. Immunodeficient mice engrafted with functional human cells and tissues, termed 'humanized' mice, represent a critical pre-clinical bridge for in vivo studies of human pathogens. Recent advances in the development of humanized mice have allowed in vivo studies of multiple human infectious agents providing novel insights into their pathogenesis that was otherwise not possible. Curr Opin Immunol 2013 Aug; 25(4):428-35.
Recommended Citation
Brehm M,
Jouvet N,
Greiner D,
Shultz LD.
Humanized mice for the study of infectious diseases. Curr Opin Immunol 2013 Aug; 25(4):428-35.