R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla.
Document Type
Article
Publication Date
3-2013
JAX Source
Exp Dermatol 2013 Mar; 22(3):234-6.
Volume
22
Issue
3
First Page
234
Last Page
236
ISSN
1600-0625
PMID
23489430
Abstract
A number of single gene mutations in laboratory mice produce hair follicle defects resulting in deformed hair shafts. The radiation-induced (SB/LeJ-Foxq1(sa)) satin mutant mice have a satin-like sheen to their hair and dilute colouration. This sheen is due to failure of the hair shafts to develop normal medullas, while the pigment dilution is due to the unrelated beige (lysosomal trafficking regulator, Lyst(bg)) mutation. A new allelic mutation, Foxq1(sa-J), arose spontaneously on the albino (tyrosinase, Tyr(c)) MRL/MpJ-Fas(lpr) background. The Foxq1(sa-J) allele has a C to T transition at position 490. By contrast, the Foxq1(sa) mutant allele was confirmed to be a 67 base pair deletion followed by two base changes (GA to AT). Morphologic changes were similar to those seen in Hoxc13 transgenic and targeted mutant mice. This new allelic mutation provides yet another tool to investigate formation of the interior structures of hair shafts. Exp Dermatol 2013 Mar; 22(3):234-6.
Recommended Citation
Wu B,
Pratt CH,
Potter CS,
Silva KA,
Kennedy VE,
Sundberg J.
R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla. Exp Dermatol 2013 Mar; 22(3):234-6.