Strain-specific variations in cation content and transport in mouse erythrocytes.

Document Type

Article

Publication Date

5-1-2013

Keywords

Animals, Cations, Erythrocytes, Female, Humans, Ion Transport, Male, Mice, Potassium, Sex Characteristics, Sodium, Sodium-Hydrogen Antiporter, Sodium-Potassium-Exchanging ATPase, Species Specificity, Symporters

JAX Source

Physiol Genomics 2013 May 1; 45(9):343-50.

Volume

45

Issue

9

First Page

343

Last Page

350

ISSN

1531-2267

PMID

23482811

Abstract

Studies of ion transport pathophysiology in hematological disorders and tests of possible new therapeutic agents for these disorders have been carried out in various mouse models because of close functional similarities between mouse and human red cells. We have explored strain-specific differences in erythrocyte membrane physiology in 10 inbred mouse strains by determining erythrocyte contents of Na(+), K(+), and Mg(2+), and erythrocyte transport of ions via the ouabain-sensitive Na-K pump, the amiloride-sensitive Na-H exchanger (NHE1), the volume and chloride-dependent K-Cl cotransporter (KCC), and the charybdotoxin-sensitive Gardos channel (KCNN4). Our data reveal substantial strain-specific and sex-specific differences in both ion content and trans-membrane ion transport in mouse erythrocytes. These differences demonstrate the feasibility of identifying specific quantitative trait loci for erythroid ion transport and content in genetically standardized inbred mouse strains. Physiol Genomics 2013 May 1; 45(9):343-50.

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