Protein Ontology: a controlled structured network of protein entities.
Document Type
Article
Publication Date
1-1-2014
JAX Source
Nucleic Acids Res 2014 Jan 1; 42(1):D415-21.
Volume
42
Issue
1
First Page
415
Last Page
421
ISSN
1362-4962
PMID
24270789
Abstract
The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to UniProtKB in that PRO's organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO's representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. Nucleic Acids Res 2014 Jan 1; 42(1):D415-21.
Recommended Citation
Natale D,
Arighi C,
Blake JA,
Bult CJ,
Christie KR,
Cowart J,
D'Eustachio P,
Diehl A,
Drabkin HJ,
Helfer O,
Huang H,
Masci A,
Ren J,
Roberts N,
Ross K,
Ruttenberg A,
Shamovsky V,
Smith B,
Yerramalla M,
Zhang J,
Aljanahi A,
Celen I,
Gan C,
Lv M,
Schuster-Lezell E,
Wu C.
Protein Ontology: a controlled structured network of protein entities. Nucleic Acids Res 2014 Jan 1; 42(1):D415-21.