Genomic Epidemiology of Salmonella enterica Serotype Enteritidis based on Population Structure of Prevalent Lineages.
Document Type
Article
Publication Date
9-2014
JAX Source
Emerg Infect Dis 2014 Sep; 20(9):1481-9.
Volume
20
Issue
9
First Page
1481
Last Page
1489
ISSN
1080-6059
PMID
25147968
Abstract
Salmonella enterica serotype Enteritidis is one of the most commonly reported causes of human salmonellosis. Its low genetic diversity, measured by fingerprinting methods, has made subtyping a challenge. We used whole-genome sequencing to characterize 125 S. enterica Enteritidis and 3 S. enterica serotype Nitra strains. Single-nucleotide polymorphisms were filtered to identify 4,887 reliable loci that distinguished all isolates from each other. Our whole-genome single-nucleotide polymorphism typing approach was robust for S. enterica Enteritidis subtyping with combined data for different strains from 2 different sequencing platforms. Five major genetic lineages were recognized, which revealed possible patterns of geographic and epidemiologic distribution. Analyses on the population dynamics and evolutionary history estimated that major lineages emerged during the 17th-18th centuries and diversified during the 1920s and 1950s. Emerg Infect Dis 2014 Sep; 20(9):1481-9.
Recommended Citation
Deng X,
Desai P,
den Bakker H,
Mikoleit M,
Tolar B,
Trees E,
Hendriksen R,
Frye J,
Porwollik S,
Weimer B,
Wiedmann M,
Weinstock GM,
Fields P,
McClelland M.
Genomic Epidemiology of Salmonella enterica Serotype Enteritidis based on Population Structure of Prevalent Lineages. Emerg Infect Dis 2014 Sep; 20(9):1481-9.