Genetically engineered humanized mouse models for preclinical antibody studies.
Document Type
Article
Publication Date
4-2014
JAX Location
Reprint Collection
JAX Source
BioDrugs 2014 Apr; 28(2):171-80.
Volume
28
Issue
2
First Page
171
Last Page
180
ISSN
1173-8804
PMID
24150980
Abstract
The use of genetic engineering has vastly improved our capabilities to create animal models relevant in preclinical research. With the recent advances in gene-editing technologies, it is now possible to very rapidly create highly tunable mouse models as needs arise. Here, we provide an overview of genetic engineering methods, as well as the development of humanized neonatal Fc receptor (FcRn) models and their use for monoclonal antibody in vivo studies.
Recommended Citation
Proetzel G,
Wiles MV,
Roopenian DC.
Genetically engineered humanized mouse models for preclinical antibody studies. BioDrugs 2014 Apr; 28(2):171-80.
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