Title

Consensus nomenclature for CD8(+) T cell phenotypes in cancer.

Document Type

Article

Publication Date

4-1-2015

JAX Location

Reprint Collection

JAX Source

Oncoimmunology 2015 Apr; 4(4):e998538

Volume

4

Issue

4

First Page

998538

Last Page

998538

ISSN

2162-4011

PMID

26137416

Abstract

Whereas preclinical investigations and clinical studies have established that CD8(+) T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8(+) T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8(+) T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8(+) T cell immunity, leading to the emergence of dysfunctional CD8(+) T cells. The existence of different types of CD8(+) T cells in cancer calls for a more precise definition of the CD8(+) T cell immune phenotypes in cancer and the abandonment of the generic terms "pro-tumor" and "antitumor." Based on recent studies investigating the functions of CD8(+) T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8(+) T cells in cancer. Oncoimmunology 2015 Apr; 4(4):e998538

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