Diet dominates host genotype in shaping the murine gut microbiota.

Document Type

Article

Publication Date

1-14-2015

JAX Source

Cell Host Microbe 2015 Jan 14; 17(1):72-84.

Volume

17

Issue

1

First Page

72

Last Page

84

ISSN

1934-6069

PMID

25532804

Grant

GM068763, GM076468, DK101154

Abstract

Mammals exhibit marked interindividual variations in their gut microbiota, but it remains unclear if this is primarily driven by host genetics or by extrinsic factors like dietary intake. To address this, we examined the effect of dietary perturbations on the gut microbiota of five inbred mouse strains, mice deficient for genes relevant to host-microbial interactions (MyD88(-/-), NOD2(-/-), ob/ob, and Rag1(-/-)), and >200 outbred mice. In each experiment, consumption of a high-fat, high-sugar diet reproducibly altered the gut microbiota despite differences in host genotype. The gut microbiota exhibited a linear dose response to dietary perturbations, taking an average of 3.5 days for each diet-responsive bacterial group to reach a new steady state. Repeated dietary shifts demonstrated that most changes to the gut microbiota are reversible, while also uncovering bacteria whose abundance depends on prior consumption. These results emphasize the dominant role that diet plays in shaping interindividual variations in host-associated microbial communities. Cell Host Microbe 2015 Jan 14; 17(1):72-84.

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