Title
The transcriptional landscape of age in human peripheral blood.
Document Type
Article
Publication Date
10-22-2015
JAX Source
Nat Commun 2015 Oct 22; 6:8570.
Volume
6
First Page
8570
Last Page
8570
ISSN
2041-1723
PMID
26490707
Abstract
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts. Nat Commun 2015 Oct 22; 6:8570.
Recommended Citation
Peters M,
Joehanes R,
Pilling L,
Schurmann C,
Conneely K,
Powell J,
Reinmaa E,
Sutphin GL,
Zhernakova A,
Schramm K,
Wilson Y,
Kobes S,
Tukiainen T,
Ramos Y,
Göring H,
Fornage M,
Liu Y,
Gharib S,
Stranger B,
De Jager P,
Aviv A,
Levy D,
Murabito J,
Munson P,
Huan T,
Hofman A,
Uitterlinden A,
Rivadeneira F,
van Rooij J,
Stolk L,
Broer L,
Verbiest M,
Jhamai M,
Arp P,
Metspalu A,
Tserel L,
Milani L,
Samani N,
Peterson P,
Kasela S,
Codd V,
Peters A,
Ward-Caviness C,
Herder C,
Waldenberger M,
Roden M,
Singmann P,
Zeilinger S,
Illig T,
Homuth G,
Grabe H,
Völzke H,
Steil L,
Kocher T,
Murray A,
Melzer D,
Yaghootkar H,
Bandinelli S,
Moses E,
Kent J,
Curran J,
Johnson M,
Williams-Blangero S,
Westra H,
McRae A,
Smith J,
Kardia S,
Hovatta I,
Perola M,
Ripatti S,
Salomaa V,
Henders A,
Martin N,
Smith A,
Mehta D,
Binder E,
Nylocks K,
Kennedy E,
Klengel T,
Ding J,
Suchy-Dicey A,
Enquobahrie D,
Brody J,
Rotter J,
Chen Y,
Houwing-Duistermaat J,
Kloppenburg M,
Slagboom P,
Helmer Q,
den Hollander W,
Bean S,
Raj T,
Bakhshi N,
Wang Q,
Oyston L,
Psaty B,
Tracy R,
Montgomery G,
Turner S,
Blangero J,
Meulenbelt I,
Ressler K,
Yang J,
Franke L,
Kettunen J,
Visscher P,
Neely G,
Korstanje R,
Hanson R,
Prokisch H,
Ferrucci L,
Esko T,
Teumer A,
van Meurs J,
Johnson A.
The transcriptional landscape of age in human peripheral blood. Nat Commun 2015 Oct 22; 6:8570.