Title
ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.
Document Type
Article
Publication Date
3-27-2015
JAX Source
Nat Commun 2015 Mar 27; 6:6548.
Volume
6
First Page
6548
Last Page
6548
ISSN
2041-1723
PMID
25813983
Abstract
Basal-like breast cancer (BLBC) is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. In this study, we show that inhibitor of differentiation 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with a putative mammary basal cell of origin. Using an ID4GFP knock-in reporter mouse and single-cell transcriptomics, we show that ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation. Furthermore, ID4 is specifically expressed by a subset of human BLBC that possess a very poor prognosis and a transcriptional signature similar to a mammary stem cell. These studies identify ID4 as a mammary stem cell regulator, deconvolute the heterogeneity of BLBC and link a subset of mammary stem cells to the aetiology of BLBC. Nat Commun 2015 Mar 27; 6:6548.
Recommended Citation
Junankar S,
Baker L,
Roden D,
Nair R,
Elsworth B,
Gallego-Ortega D,
Lacaze P,
Cazet A,
Nikolic I,
Teo W,
Yang J,
McFarland A,
Harvey K,
Naylor M,
Lakhani S,
Simpson P,
Raghavendra A,
Saunus J,
Madore J,
Kaplan W,
Ormandy C,
Millar E,
O'Toole S,
Yun K,
Swarbrick A.
ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype. Nat Commun 2015 Mar 27; 6:6548.