Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.
Document Type
Article
Publication Date
6-1-2016
JAX Source
Nat Genet 2016 Jun; 48(6): 593-9
Volume
48
Issue
6
First Page
593
Last Page
599
ISSN
1546-1718
PMID
27111036
Abstract
We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26 worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 variants, including single-nucleotide variants, multiple-nucleotide variants, insertions and deletions, short tandem repeats, and copy number variants. Of these, copy number variants contribute the greatest predicted functional impact. We constructed a calibrated phylogenetic tree on the basis of binary single-nucleotide variants and projected the more complex variants onto it, estimating the number of mutations for each class. Our phylogeny shows bursts of extreme expansion in male numbers that have occurred independently among each of the five continental superpopulations examined, at times of known migrations and technological innovations. Nat Genet 2016 Jun; 48(6): 593-9
Recommended Citation
Poznik G,
Xue Y,
Mendez F,
Willems T,
Massaia A,
Wilson Sayres M,
Ayub Q,
McCarthy S,
Narechania A,
Kashin S,
Chen Y,
Banerjee R,
Rodriguez-Flores J,
Cerezo M,
Shao H,
Gymrek M,
Malhotra A,
Louzada S,
Desalle R,
Ritchie G,
Cerveira E,
Fitzgerald T,
Garrison E,
Marcketta A,
Mittelman D,
Romanovitch M,
Zhang C,
Zheng-Bradley X,
Abecasis G,
McCarroll S,
Flicek P,
Underhill P,
Coin L,
Zerbino D,
Yang F,
Lee C,
Clarke L,
Auton A,
Erlich Y,
Handsaker R,
Bustamante C,
Tyler-Smith C.
Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences. Nat Genet 2016 Jun; 48(6): 593-9