Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics.

Document Type

Article

Publication Date

9-2016

JAX Source

Trends Biotechnol 2016 Sep; 34(9):722-32

Volume

34

Issue

9

First Page

722

Last Page

732

ISSN

1879-3096

PMID

27296078

Abstract

Improving the ability to predict the efficacy and toxicity of drug candidates earlier in the drug discovery process will speed up the introduction of new drugs into clinics. 3D in vitro systems have significantly advanced the drug screening process as 3D tissue models can closely mimic native tissues and, in some cases, the physiological response to drugs. Among various in vitro systems, bioprinting is a highly promising technology possessing several advantages such as tailored microarchitecture, high-throughput capability, coculture ability, and low risk of cross-contamination. In this opinion article, we discuss the currently available tissue models in pharmaceutics along with their limitations and highlight the possibilities of bioprinting physiologically relevant tissue models, which hold great potential in drug testing, high-throughput screening, and disease modeling. Trends Biotechnol 2016 Sep; 34(9):722-32.

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