Humanized Mouse Models for Transplant Immunology.

Document Type

Article

Publication Date

2-2016

JAX Location

Reprint Collection

JAX Source

Am J Transplant 2016 Feb; 16(2):389-97.

Volume

16

Issue

2

First Page

389

Last Page

397

ISSN

1600-6143

PMID

26588186

Abstract

Our understanding of the molecular pathways that control immune responses, particularly immunomodulatory molecules that control the extent and duration of an immune response, have led to new approaches in the field of transplantation immunology to induce allograft survival. These molecular pathways are being defined precisely in murine models and translated into clinical practice; however, many of the newly available drugs are human-specific reagents. Furthermore, many species-specific differences exist between mouse and human immune systems. Recent advances in the development of humanized mice, namely, immunodeficient mice engrafted with functional human immune systems, have led to the availability of a small animal model for the study of human immune responses. Humanized mice represent an important preclinical model system for evaluation of new drugs and identification of the mechanisms underlying human allograft rejection without putting patients at risk. This review highlights recent advances in the development of humanized mice and their use as preclinical models for the study of human allograft responses. Am J Transplant 2016 Feb; 16(2):389-97.

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