Prevalence of sexual dimorphism in mammalian phenotypic traits.
Document Type
Article
Publication Date
6-26-2017
JAX Source
Nat Commun 2017 Jun 26; 8:15475
Volume
8
First Page
15475
Last Page
15475
ISSN
2041-1723
PMID
28650954
DOI
https://doi.org/10.1038/ncomms15475
Abstract
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
Nat Commun 2017 Jun 26; 8:15475.
Recommended Citation
Karp N,
Mason J,
Beaudet A,
Benjamini Y,
Bower L,
Braun R,
Brown S,
Chesler E,
Dickinson M,
Flenniken A,
Fuchs H,
Angelis M,
Gao X,
Guo S,
Greenaway S,
Heller R,
Herault Y,
Justice M,
Kurbatova N,
Lelliott C,
Lloyd K,
Mallon A,
Mank J,
Masuya H,
McKerlie C,
Meehan T,
Mott R,
Murray SA,
Parkinson H,
Ramirez-Solis R,
Santos L,
Seavitt J,
Smedley D,
Sorg T,
Speak A,
Steel K,
Svenson KL,
Wakana S,
West D,
Wells S,
Westerberg H,
Yaacoby S,
White J.
Prevalence of sexual dimorphism in mammalian phenotypic traits. Nat Commun 2017 Jun 26; 8:15475