Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.
Document Type
Article
Publication Date
8-15-2017
JAX Source
Immunity 2017 Aug 15; 47(2):310-322.
Volume
47
Issue
2
First Page
310
Last Page
322
ISSN
1097-4180
PMID
28813660
DOI
https://doi.org/10.1016/j.immuni.2017.07.013
Abstract
Select humans and animals control persistent viral infections via adaptive immune responses that include production of neutralizing antibodies. The precise genetic basis for the control remains enigmatic. Here, we report positional cloning of the gene responsible for production of retrovirus-neutralizing antibodies in mice of the I/LnJ strain. It encodes the beta subunit of the non-classical major histocompatibility complex class II (MHC-II)-like molecule H2-O, a negative regulator of antigen presentation. The recessive and functionally null I/LnJ H2-Ob allele supported the production of virus-neutralizing antibodies independently of the classical MHC haplotype. Subsequent bioinformatics and functional analyses of the human H2-Ob homolog, HLA-DOB, revealed both loss- and gain-of-function alleles, which could affect the ability of their carriers to control infections with human hepatitis B (HBV) and C (HCV) viruses. Thus, understanding of the previously unappreciated role of H2-O (HLA-DO) in immunity to infections may suggest new approaches in achieving neutralizing immunity to viruses. Immunity 2017 Aug 15; 47(2):310-322.
Recommended Citation
Denzin L,
Khan A,
Virdis F,
Wilks J,
Kane M,
Beilinson H,
Dikiy S,
Case L,
Roopenian DC,
Witkowski M,
Chervonsky A,
Golovkina T.
Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob. Immunity 2017 Aug 15; 47(2):310-322.