QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzene Toxicity Experiment.
Document Type
Article
Publication Date
2017
JAX Location
Reprint Collection
JAX Source
Methods Mol Biol 2017; 1488:265-281
Volume
1488
First Page
265
Last Page
281
ISSN
1940-6029
PMID
27933529
DOI
https://doi.org/10.1007/978-1-4939-6427-7_12
Grant
GM076468, GM070683
Abstract
Diversity Outbred (DO) mice are a multiparental advanced generation intercross population derived from eight inbred strains which are genetically very diverse. They are maintained as an outbred population using a randomized mating design. Thus DO mice represent an ideal population to map phenotypic traits. Here, we provide a case study in which male DO mice were exposed to benzene and phenotyped for the number of micronucleated reticulocytes. We provide step-by-step R scripts for the analysis of phenotypes, genotypes, mapping of resistance gene loci and identification of candidate genes. Methods Mol Biol 2017; 1488:265-281.
Recommended Citation
Gatti DM,
French J,
Schughart K.
QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzene Toxicity Experiment. Methods Mol Biol 2017; 1488:265-281