PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.
Document Type
Article
Publication Date
11-1-2017
JAX Source
Cancer Res 2017 Nov 1; 77(21):e62-e66.
Volume
77
Issue
21
First Page
62
Last Page
62
ISSN
1538-7445
PMID
29092942
DOI
https://doi.org/10.1158/0008-5472.CAN-17-0582
Grant
CA089713D, CA034196
Abstract
Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models. PDX-MI defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use of PDX models in cancer research. Adherence to PDX-MI standards will facilitate accurate search results for oncology models and their associated data across distributed repository databases and promote reproducibility in research studies using these models. Cancer Res; 77(21); e62-66. ©2017 AACR.
Recommended Citation
Meehan T,
Conte N,
Goldstein T,
Inghirami G,
Murakami M,
Brabetz S,
Gu Z,
Wiser J,
Dunn P,
Begley DA,
Krupke DM,
Bertotti A,
Bruna A,
Brush M,
Byrne A,
Caldas C,
Christie A,
Clark D,
Dowst H,
Dry J,
Doroshow J,
Duchamp O,
Evrard Y,
Ferretti S,
Frese K,
Goodwin N,
Greenawalt D,
Haendel M,
Hermans E,
Houghton P,
Jonkers J,
Kemper K,
Khor T,
Lewis M,
Lloyd K,
Mason J,
Medico E,
Neuhauser S,
Olson J,
Peeper D,
Rueda O,
Seong J,
Trusolino L,
Vinolo E,
Wechsler-Reya R,
Weinstock D,
Welm A,
Weroha S,
Amant F,
Pfister S,
Kool M,
Parkinson H,
Butte A,
Bult C.
PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Cancer Res 2017 Nov 1; 77(21):e62-e66.