Title

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

Document Type

Article

Publication Date

11-1-2017

JAX Source

Cancer Res 2017 Nov 1; 77(21):e62-e66.

PMID

29092942

DOI

https://doi.org/10.1158/0008-5472.CAN-17-0582

Grant

CA089713D, CA034196

Abstract

Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models. PDX-MI defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use of PDX models in cancer research. Adherence to PDX-MI standards will facilitate accurate search results for oncology models and their associated data across distributed repository databases and promote reproducibility in research studies using these models. Cancer Res; 77(21); e62-66. ©2017 AACR.