The Mouse Tumor Biology Database: A Comprehensive Resource for Mouse Models of Human Cancer.

Authors

Debra M. Krupke, The Jackson LaboratoryFollow
Dale A. Begley, The Jackson LaboratoryFollow
John P Sundberg, The Jackson LaboratoryFollow
Joel E Richardson, The Jackson LaboratoryFollow
Steven B Neuhauser, The Jackson LaboratoryFollow
Carol J Bult, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

11-1-2017

JAX Source

Cancer Res 2017 Nov 1; 77(21):e67-e70.

Volume

77

Issue

21

First Page

67

Last Page

67

ISSN

1538-7445

PMID

29092943

DOI

https://doi.org/10.1158/0008-5472.CAN-17-0584

Grant

CA089713

Abstract

Research using laboratory mice has led to fundamental insights into the molecular genetic processes that govern cancer initiation, progression, and treatment response. Although thousands of scientific articles have been published about mouse models of human cancer, collating information and data for a specific model is hampered by the fact that many authors do not adhere to existing annotation standards when describing models. The interpretation of experimental results in mouse models can also be confounded when researchers do not factor in the effect of genetic background on tumor biology. The Mouse Tumor Biology (MTB) database is an expertly curated, comprehensive compendium of mouse models of human cancer. Through the enforcement of nomenclature and related annotation standards, MTB supports aggregation of data about a cancer model from diverse sources and assessment of how genetic background of a mouse strain influences the biological properties of a specific tumor type and model utility. Cancer Res; 77(21); e67-70. ©2017 AACR.

Recommended Citation

Krupke DM, Begley DA, Sundberg J, Richardson J, Neuhauser S, Bult C. The Mouse Tumor Biology Database: A Comprehensive Resource for Mouse Models of Human Cancer. Cancer Res 2017 Nov 1; 77(21):e67-e70.