Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.
Document Type
Article
Publication Date
12-2017
JAX Source
Nat Genet 2017 Dec 49(12):1714-1721
Volume
49
Issue
12
First Page
1714
Last Page
1721
ISSN
1546-1718
PMID
29083405
DOI
https://doi.org/10.1038/ng.3959
Abstract
By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders. Nat Genet 2017 Dec 49(12):1714-1721.
Recommended Citation
Jasinska A,
Zelaya I,
Service S,
Peterson C,
Cantor R,
Choi O,
DeYoung J,
Eskin E,
Fairbanks L,
Fears S,
Furterer A,
Huang Y,
Ramensky V,
Schmitt C,
Svardal H,
Jorgensen M,
Kaplan J,
Villar D,
Aken B,
Flicek P,
Nag R,
Wong E,
Blangero J,
Dyer T,
Bogomolov M,
Benjamini Y,
Weinstock GM,
Dewar K,
Sabatti C,
Wilson R,
Jentsch J,
Warren W,
Coppola G,
Woods R,
Freimer N.
Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Nat Genet 2017 Dec 49(12):1714-1721