Ancient hybridization and strong adaptation to viruses across African vervet monkey populations.
Document Type
Article
Publication Date
12-2017
JAX Source
Nat Genet 2017 Dec; 49(12):1705-1713.
Volume
49
Issue
12
First Page
1705
Last Page
1713
ISSN
1546-1718
PMID
29083404
DOI
https://doi.org/10.1038/ng.3980
Abstract
Vervet monkeys are among the most widely distributed nonhuman primates, show considerable phenotypic diversity, and have long been an important biomedical model for a variety of human diseases and in vaccine research. Using whole-genome sequencing data from 163 vervets sampled from across Africa and the Caribbean, we find high diversity within and between taxa and clear evidence that taxonomic divergence was reticulate rather than following a simple branching pattern. A scan for diversifying selection across taxa identifies strong and highly polygenic selection signals affecting viral processes. Furthermore, selection scores are elevated in genes whose human orthologs interact with HIV and in genes that show a response to experimental simian immunodeficiency virus (SIV) infection in vervet monkeys but not in rhesus macaques, suggesting that part of the signal reflects taxon-specific adaptation to SIV. Nat Genet 2017 Dec; 49(12):1705-1713.
Recommended Citation
Svardal H,
Jasinska A,
Apetrei C,
Coppola G,
Huang Y,
Schmitt C,
Jacquelin B,
Ramensky V,
Müller-Trutwin M,
Antonio M,
Weinstock GM,
Grobler J,
Dewar K,
Wilson R,
Turner T,
Warren W,
Freimer N,
Nordborg M.
Ancient hybridization and strong adaptation to viruses across African vervet monkey populations. Nat Genet 2017 Dec; 49(12):1705-1713.