Systematic analysis of telomere length and somatic alterations in 31 cancer types.
Document Type
Article
Publication Date
3-2017
JAX Source
Nat Genet 2017 Mar; 49(3):349-357
Volume
49
Issue
3
First Page
349
Last Page
357
ISSN
1546-1718
PMID
28135248
Grant
CA034196
Abstract
Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across 31 cancer types. Telomeres were shorter in tumors than in normal tissues and longer in sarcomas and gliomas than in other cancers. Among 6,835 cancers, 73% expressed telomerase reverse transcriptase (TERT), which was associated with TERT point mutations, rearrangements, DNA amplifications and transcript fusions and predictive of telomerase activity. TERT promoter methylation provided an additional deregulatory TERT expression mechanism. Five percent of cases, characterized by undetectable TERT expression and alterations in ATRX or DAXX, demonstrated elongated telomeres and increased telomeric repeat-containing RNA (TERRA). The remaining 22% of tumors neither expressed TERT nor harbored alterations in ATRX or DAXX. In this group, telomere length positively correlated with TP53 and RB1 mutations. Our analysis integrates TERT abnormalities, telomerase activity and genomic alterations with telomere length in cancer. Nat Genet 2017 Mar; 49(3):349-357.
Recommended Citation
Barthel F,
Wei W,
Tang M,
Martinez-Ledesma E,
Hu X,
Amin S,
Akdemir K,
Seth S,
Song X,
Wang Q,
Lichtenberg T,
Hu J,
Zhang J,
Zheng S,
Verhaak R.
Systematic analysis of telomere length and somatic alterations in 31 cancer types. Nat Genet 2017 Mar; 49(3):349-357