Genomics of Islet (Dys)function and Type 2 Diabetes.

Authors

Nathan Lawlor, The Jackson LaboratoryFollow
Shubham Khetan, The Jackson LaboratoryFollow
Duygu Ucar, The Jackson LaboratoryFollow
Michael L. Stitzel, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

4-2017

JAX Source

Trends Genet 2017 Apr; 33(4):244-255

Volume

33

Issue

4

First Page

244

Last Page

255

ISSN

0168-9525

PMID

28245910

Abstract

Pancreatic islet dysfunction and beta cell failure are hallmarks of type 2 diabetes mellitus (T2DM) pathogenesis. In this review, we discuss how genome-wide association studies (GWASs) and recent developments in islet (epi)genome and transcriptome profiling (particularly single cell analyses) are providing novel insights into the genetic, environmental, and cellular contributions to islet (dys)function and T2DM pathogenesis. Moving forward, study designs that interrogate and model genetic variation [e.g., allelic profiling and (epi)genome editing] will be critical to dissect the molecular genetics of T2DM pathogenesis, to build next-generation cellular and animal models, and to develop precision medicine approaches to detect, treat, and prevent islet (dys)function and T2DM. Trends Genet 2017 Apr; 33(4):244-255.

Recommended Citation

Lawlor N, Khetan S, Ucar D, Stitzel ML. Genomics of Islet (Dys)function and Type 2 Diabetes. Trends Genet 2017 Apr; 33(4):244-255