Systems Genetic Analysis in GeneNetwork.org.
Document Type
Article
Publication Date
4-10-2017
JAX Location
Reprint Collection
JAX Source
Curr Protoc Neurosci 2017 Apr 10; 79:8.39.1-8.39.20.
Volume
79
First Page
1
Last Page
8
ISSN
1934-8576
PMID
28398643
DOI
https://doi.org/10.1002/cpns.23
Grant
DA037927, DA039841
Abstract
Genome-wide association studies (GWAS) have emerged as a powerful tool to identify alleles and molecular pathways that influence susceptibility to psychiatric disorders and other diseases. Forward genetics using mouse mapping populations allows for a complementary approach that provides rigorous genetic and environmental control. In this unit, we describe techniques and tools that reduce the technical burden traditionally associated with genetic mapping in mice and enhance their translational utility to human psychiatric disorders. We provide guidance on choosing the appropriate mapping population, discuss the importance of phenotype, and offer detailed instructions on using the Web-based resource GeneNetwork to aid neuroscientists in better understanding the mechanisms through which genes influence behavior. We believe that the continued development of mouse mapping populations, genetic tools, bioinformatics resources, and statistical methodologies should remain a parallel strategy by which to investigate the genetic and environmental underpinnings of psychiatric disorders and other diseases in humans. Curr Protoc Neurosci 2017 Apr 10; 79:8.39.1-8.39.20© 2017 by John Wiley & Sons, Inc.
Recommended Citation
Parker C,
Dickson PE,
Philip VM,
Thomas M,
Chesler E.
Systems Genetic Analysis in GeneNetwork.org. Curr Protoc Neurosci 2017 Apr 10; 79:8.39.1-8.39.20.