Title

Assessing Healthspan and Lifespan Measures in Aging Mice: Optimization of Testing Protocols, Replicability, and Rater Reliability.

Document Type

Article

Publication Date

6-20-2018

JAX Location

Reprint Collection

JAX Source

Curr Protoc Mouse Biol 2018 Jun 20;e45

PMID

29924918

DOI

https://doi.org/10.1002/cpmo.45

Abstract

The relationship between chronological age (lifespan) and biological age (healthspan) varies amongst individuals. Understanding the normal trajectory and characteristic traits of aging mice throughout their lifespan is important for selecting the most reliable and reproducible measures to test hypotheses. The protocols herein describe assays used for aging studies at The Jackson Laboratory's Mouse Neurobehavioral Phenotyping Facility and include assessments of frailty, cognition, and sensory (hearing, vision, olfaction), motor, and fine motor function that can be used for assessing phenotypes in aged mice across their lifespan as well as provide guidance for setting up and validating these behavioral measures. Researchers aiming to study aging phenotypes require access to aged mice as a reference when initiating these types of studies in order to observe normal aging characteristics that cannot be observed in young adult mouse populations. © 2018 by John Wiley & Sons, Inc.

Comments

This work was supported by The Jackson Laboratory’s Center for Biometric Analysis.

Please contact the Joan Staats Library for information regarding this document.

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