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Submissions from 2018

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Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis., Georges Abboud, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Derry C. Roopenian, and Laurence Morel

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Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma., Seçkin Akgül, Yinghua Li, Siyuan Zheng, Marcel Kool, Daniel M Treisman, Chaoyang Li, Yuan Wang, Susanne Gröbner, Tsuneo Ikenoue, Yiping Shen, Sandra Camelo-Piragua, Gerald Tomasek, Sebastian Stark, Vinay Guduguntla, James F Gusella, Kun-Liang Guan, Stefan M Pfister, Roel G W Verhaak, and Yuan Zhu

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Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells., Mohammad Alsady, Theun de Groot, Marleen L A Kortenoeven, Claudia Carmone, Kim Neijman, Melissa Bekkenkamp-Grovenstein, Udo Engelke, Ron Wevers, Ruben Baumgarten, Ron Korstanje, and Peter M T Deen

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NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network., David J Anderson, David I Kaplan, Katrina M Bell, Katerina Koutsis, John M Haynes, Richard J Mills, Dean G Phelan, Elizabeth L Qian, Ana Rita Leitoguinho, Deevina Arasaratnam, Tanya Labonne, Elizabeth S Ng, Richard P Davis, Simona Casini, Robert Passier, James E Hudson, Enzo R Porrello, Mauro W Costa, Arash Rafii, Clare L Curl, Lea M Delbridge, Richard P Harvey, Alicia Oshlack, Michael M Cheung, Christine L Mummery, Stephen Petrou, Andrew G Elefanty, Edouard G Stanley, and David A Elliott

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Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation., Pachiappan Arjunan, Mohamed M Meghil, Wenhu Pi, Jinxian Xu, Liwei Lang, Ahmed El-Awady, William Sullivan, Mythilypriya Rajendran, Mariana Sousa Rabelo, Tong Wang, Omnia K Tawfik, Govindarajan Kunde-Ramamoorthy, Nagendra Singh, Thangaraju Muthusamy, Cristiano Susin, Yong Teng, Roger M Arce, and Christopher W Cutler

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FAR2 is Associated with Kidney Disease in Mice and Humans., Grant Backer, Sean Eddy, Susan Sheehan, Yuka Takemon, Anna Reznichenko, Holly S Savage, Matthias Kretzler, and Ron Korstanje

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Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery., Baharak Bahmani, Mayuko Uehara, Farideh Ordikhani, Xiaofei Li, Liwei Jiang, Naima Banouni, Takaharu Ichimura, Vivek Kasinath, Siawosh K Eskandari, Nasim Annabi, Jonathan S Bromberg, Leonard D. Shultz, Dale L Greiner, and Reza Abdi

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Capturing Totipotent Stem Cells., Christopher L. Baker and Martin F Pera

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Immunotherapy: Cancer vaccines on the move., Jacques Banchereau and Karolina Palucka

Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults., Floris P Barthel, Kevin C Johnson, Pieter Wesseling, and Roel G W Verhaak

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Reconstructing the molecular life history of gliomas., Floris P Barthel, Pieter Wesseling, and Roel G W Verhaak

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FusorSV: an algorithm for optimally combining data from multiple structural variation detection methods., Timothy Becker, Wan-Ping Lee, Joseph Leone, Qihui Zhu, Chengsheng Zhang, Silvia Liu, Jack Sargent, Kritika Shanker, Adam Mil-Homens, Eliza Cerveira, Mallory Ryan, Jane Cha, Fabio C P Navarro, Timur Galeev, Mark Gerstein, Ryan E Mills, Dong-Guk Shin, Charles Lee, and Ankit Malhotra

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Disease Ontology: improving and unifying disease annotations across species., Susan M. Bello, Mary Shimoyama, Elvira Mitraka, Stanley J F Laulederkind, Cynthia Smith, Janan T. Eppig, and Lynn M Schriml

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The HDAC3-SMARCA4-miR-27a axis promotes expression of the, Narendra Bharathy, Noah E Berlow, Eric Wang, Jinu Abraham, Teagan P Settelmeyer, Jody E Hooper, Matthew N Svalina, Yoshihiro Ishikawa, Keith Zientek, Zia Bajwa, Martin W Goros, Brian S Hernandez, Johannes E Wolff, Michelle A Rudek, Linping Xu, Nicole M Anders, Ranadip Pal, Alexandria P Harrold, Angela M Davies, Arya Ashok, Darnell Bushby, Maria Mancini, Christopher Noakes, Neal C Goodwin, Peter Ordentlich, James G. Keck, Douglas S Hawkins, Erin R Rudzinski, Bishwanath Chatterjee, Hans Peter Bächinger, Frederic G Barr, Jennifer Liddle, Benjamin A Garcia, Atiya Mansoor, Theodore J Perkins, Christopher R Vakoc, Joel E Michalek, and Charles Keller

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Role of metabolic spatiotemporal dynamics in regulating biofilm colony expansion., Federico Bocci, Yoko Suzuki, Mingyang Lu, and José N Onuchic

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Mouse Phenome Database: an integrative database and analysis suite for curated empirical phenotype data from laboratory mice., Molly A. Bogue, Stephen C. Grubb, David O Walton, Vivek M. Philip, Georgi Kolishovski, Timothy M Stearns, Matthew H Dunn, Daniel A Skelly, Beena Kadakkuzha, Gregg TeHennepe, Govindarajan Kunde-Ramamoorthy, and Elissa J Chesler

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Meiosis: the chromosomal foundation of reproduction., Ewelina Bolcun-Filas and Mary Ann Handel

Circulating serum oncologic miRNA in pediatric juvenile pilocytic astrocytoma patients predicts mural nodule volume., Markus Bookland, Min D Tang-Schomer, Eileen Gillan, and Antonina Kolmakova

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α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes., Marcela Brissova, Rachana Haliyur, Diane Saunders, Shristi Shrestha, Chunhua Dai, David M Blodgett, Rita Bottino, Martha Campbell-Thompson, Radhika Aramandla, Gregory Poffenberger, Jill Lindner, Fong Cheng Pan, Matthias G von Herrath, Dale L Greiner, Leonard D. Shultz, May Sanyoura, Louis H Philipson, Mark Atkinson, David M Harlan, Shawn E Levy, Nripesh Prasad, Roland Stein, and Alvin C Powers

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Frataxin-deficient neurons and mice models of Friedreich ataxia are improved by TAT-MTScs-FXN treatment., Elena Britti, Fabien Delaspre, Anat Feldman, Melissa Osborne, Hagar Greif, Jordi Tamarit, and Joaquim Ros

Chromatin Immunoprecipitation for Chromatin Interaction Analysis Using Paired-End-Tag (ChIA-PET) Sequencing in Tadpole Tissues., Nicolas Buisine, Xiaoan Ruan, Yijun Ruan, and Laurent M Sachs

Chromatin Interaction Analysis Using Paired-End-Tag (ChIA-PET) Sequencing in Tadpole Tissues., Nicolas Buisine, Xiaoan Ruan, Yijun Ruan, and Laurent M Sachs

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Editorial: Axonopathy in Neurodegenerative Disease., Robert W. Burgess and Samuel D Crish

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In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions., S R Burstein, F Valsecchi, H Kawamata, M Bourens, R Zeng, Aamir Zuberi, T A Milner, S M Cloonan, Cathleen Lutz, A Barrientos, and G Manfredi

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Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis., Zhigang Cai, Jonathan J Kotzin, Baskar Ramdas, Sisi Chen, Sai Nelanuthala, Lakshmi Reddy Palam, Ruchi Pandey, Raghuveer Singh Mali, Yan Liu, Mark R Kelley, George Sandusky, Morvarid Mohseni, Adam Williams, Jorge Henao-Mejia, and Reuben Kapur

The "adipose tissue expandability" hypothesis: a potential mechanism for insulin resistance in obese youth., Sonia Caprio, Bridget Pierpont, and Romy Kursawe

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Sox2 conditional mutation in mouse causes ataxic symptoms, cerebellar vermis hypoplasia, and postnatal defects of Bergmann glia., Valentina Cerrato, Sara Mercurio, Ketty Leto, Elisa Fucà, Eriola Hoxha, Sara Bottes, Miriam Pagin, Marco Milanese, Chew Yee Ngan, Giulia Concina, Sergio Ottolenghi, Chia-Lin Wei, Giambattista Bonanno, Giulio Pavesi, Filippo Tempia, Annalisa Buffo, and Silvia K Nicolis

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Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma., Young Kwang Chae, Jonathan F Anker, Preeti Bais, Sandeep Namburi, Francis J Giles, and Jeffrey H Chuang

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Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele., Bo Chang, Bernie Fitzmaurice, Jieping Wang, Benjamin E. Low, Michael V. Wiles, and Patsy M. Nishina

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JEPEGMIX2: improved gene-level joint analysis of eQTLs in cosmopolitan cohorts., Chris Chatzinakos, Donghyung Lee, Bradley T Webb, Vladimir I Vladimirov, Kenneth S Kendler, and Silviu-Alin Bacanu

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Functional Interrogation of Primary Human T Cells via CRISPR Genetic Editing., Xin Chen, Lina Kozhaya, Cihan Tastan, Lindsey Placek, Mikail Dogan, Meghan Horne, Rebecca Abblett, Ece Karhan, Martin Vaeth, Stefan Feske, and Derya Unutmaz

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Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells., Seung-Chul Choi, Anton A Titov, Georges Abboud, Howard R Seay, Todd M Brusko, Derry C. Roopenian, Shahram Salek-Ardakani, and Laurence Morel

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Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4, Seung-Chul Choi, Zhiwei Xu, Wei Li, Hong Yang, Derry C. Roopenian, Herbert C Morse, and Laurence Morel

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Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice., Yunsik Choi, Sanghyuk Lee, Kapyoul Kim, Soo-Hyun Kim, Yeun-Jun Chung, and Charles Lee

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Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions., Anant Chopra, Matthew L Kutys, Kehan Zhang, William J Polacheck, Calvin C Sheng, Rebeccah J Luu, Jeroen Eyckmans, J Travis Hinson, Jonathan G Seidman, Christine E Seidman, and Christopher S Chen

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Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy., Caroline Choquet, Thi Hong Minh Nguyen, Pierre Sicard, Emeline Buttigieg, Thi Thom Tran, Frank Kober, Isabelle Varlet, Rachel Sturny, Mauro W Costa, Richard P Harvey, Catherine Nguyen, Pascal Rihet, Sylvain Richard, Monique Bernard, Robert G Kelly, Nathalie Lalevée, and Lucile Miquerol

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A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci., Hélène Choquet, Seyyedhassan Paylakhi, Stephen C. Kneeland, Khanh K Thai, Thomas J Hoffmann, Jie Yin, Mark N Kvale, Yambazi Banda, Nicholas G Tolman, Pete A. Williams, Catherine Schaefer, Ronald B Melles, Neil Risch, Simon W M John, K Saidas Nair, and Eric Jorgenson

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Alterations in the Rho pathway contribute to Epstein-Barr virus-induced lymphomagenesis in immunosuppressed environments., Sung-Yup Cho, Chang Ohk Sung, Jeesoo Chae, Jieun Lee, Deukchae Na, Wonyoung Kang, Jinjoo Kang, Seoyeon Min, Ahra Lee, Eunhye Kwak, Jooyoung Kim, Boram Choi, Hyunsoo Kim, Jeffrey H Chuang, Hyo-Kyung Pak, Chan-Sik Park, Sanghui Park, Young Hyeh Ko, Dakeun Lee, Jin Roh, Min-Sun Cho, Seongyeol Park, Young Seok Ju, Yun-Suhk Suh, Seong-Ho Kong, Hyuk-Joon Lee, James Keck, Jacques Banchereau, Edison T Liu, Woo-Ho Kim, Hansoo Park, Han-Kwang Yang, Jong-Il Kim, and Charles Lee

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Sensing the cilium, digital capture of ciliary data for comparative genomics investigations., Karen R. Christie and Judith A. Blake

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Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota., Francesca Cignarella, Claudia Cantoni, Laura Ghezzi, Amber Salter, Yair Dorsett, Lei Chen, Daniel S Phillips, George M. Weinstock, Luigi Fontana, Anne H Cross, Yanjiao Zhou, and Laura Piccio

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Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling., Enrique J Cobos, Chelsea A Nickerson, Fuying Gao, Vijayendran Chandran, Inmaculada Bravo-Caparrós, Rafael González-Cano, Priscilla Riva, Nick A Andrews, Alban Latremoliere, Corey R Seehus, Gloria Perazzoli, Francisco R Nieto, Nicole Joller, Michio W Painter, Chi Him Eddie Ma, Takao Omura, Elissa J Chesler, Daniel H Geschwind, Giovanni Coppola, Manu Rangachari, Clifford J Woolf, and Michael Costigan

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Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium., The GLASS Consortium, Hoon Kim, and Roel G W Verhaak

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Mean-Variance QTL Mapping Identifies Novel QTL for Circadian Activity and Exploratory Behavior in Mice., Robert W Corty, Vivek Kumar, Lisa M Tarantino, Joseph S Takahashi, and William Valdar

Enterotypes in the landscape of gut microbial community composition., Paul I Costea, Falk Hildebrand, Arumugam Manimozhiyan, Fredrik Bäckhed, Martin J Blaser, Frederic D Bushman, Willem M de Vos, S Dusko Ehrlich, Claire M Fraser, Masahira Hattori, Curtis Huttenhower, Ian B Jeffery, Dan Knights, James D Lewis, Ruth E Ley, Howard Ochman, Paul W O'Toole, Christopher Quince, David A Relman, Fergus Shanahan, Shinichi Sunagawa, Jun Wang, George M. Weinstock, Gary D Wu, Georg Zeller, Liping Zhao, Jeroen Raes, Rob Knight, and Peer Bork

Sex- and Strain-related Differences in the Stress Response of Mice to CO₂ Euthanasia., Michelle A Creamer-Hente, Fironica K Lao, Zala P Dragos, and Linda L Waterman

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Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling., Hannah A DeBerg, Mussaret B Zaidi, Matthew C Altman, Prasong Khaenam, Vivian H Gersuk, Freddy D Campos, Iza Perez-Martinez, Mario Meza-Segura, Damien Chaussabel, Jacques Banchereau, Teresa Estrada-Garcia, and Peter S Linsley

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Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma., Ana C deCarvalho, Hoon Kim, Laila M Poisson, Mary E Winn, Claudius Mueller, David Cherba, Julie Koeman, Sahil Seth, Alexei Protopopov, Michelle Felicella, Siyuan Zheng, Asha Multani, Yongying Jiang, Jianhua Zhang, Do-Hyun Nam, Emanuel F Petricoin, Lynda Chin, Tom Mikkelsen, and Roel G W Verhaak

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Exploring autophagy with Gene Ontology., Paul Denny, Marc Feuermann, David P. Hill, Ruth C Lovering, Helene Plun-Favreau, and Paola Roncaglia

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Exploring autophagy with Gene Ontology., Paul Denny, Marc Feuermann, David P. Hill, Ruth C Lovering, Helene Plun-Favreau, and Paola Roncaglia

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The innate immune response to ischemic injury: a multiscale modeling perspective., Elena Dimitrova, Leslie A Caromile, Reinhard Laubenbacher, and Linda H Shapiro

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TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis., Pilar M Dominguez, Hussein Ghamlouch, Wojciech Rosikiewicz, Parveen Kumar, Wendy Béguelin, Lorena Fontán, Martín A Rivas, Patrycja Pawlikowska, Marine Armand, Enguerran Mouly, Miguel Torres-Martin, Ashley S Doane, María T Calvo Fernandez, Matt Durant, Veronique Della-Valle, Matt Teater, Luisa Cimmino, Nathalie Droin, Saber Tadros, Samaneh Motanagh, Alan H Shih, Mark A Rubin, Wayne Tam, Iannis Aifantis, Ross L Levine, Olivier Elemento, Giorgio Inghirami, Michael R Green, Maria E Figueroa, Olivier A Bernard, Said Aoufouchi, Sheng Li, Rita Shaknovich, and Ari M Melnick

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The polo-like kinase 1 inhibitor volasertib synergistically increases radiation efficacy in glioma stem cells., Jianwen Dong, Soon Young Park, Nghi Nguyen, Ravesanker Ezhilarasan, Emmanuel Martinez-Ledesma, Shaofang Wu, Verlene Henry, Yuji Piao, Ningyi Tiao, David Brunell, Clifford Stephan, Roel G W Verhaak, Erik Sulman, Veerakumar Balasubramaniyan, and John F de Groot

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SARNAclust: Semi-automatic detection of RNA protein binding motifs from immunoprecipitation data., Ivan Dotu, Scott I Adamson, Benjamin Coleman, Cyril Fournier, Emma Ricart-Altimiras, Eduardo Eyras, and Jeffrey H Chuang

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Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza., Jake Dunning, Simon Blankley, Long T Hoang, Mike Cox, Christine M Graham, Philip L James, Chloe I Bloom, Damien Chaussabel, Jacques Banchereau, Stephen J Brett, MOSAIC Investigators, Miriam F Moffatt, Anne O'Garra, and Peter J M Openshaw

Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice., Philip A Durost, Ken-Edwin Aryee, Fatima Manzoor, Roland M Tisch, Christian Mueller, Agata Jurczyk, Leonard D. Shultz, and Michael A Brehm

Human dental stem cell derived transgene-free iPSCs generate functional neurons via embryoid body-mediated and direct induction methods., Ikbale El Ayachi, Jun Zhang, Xiao-Ying Zou, Dong Li, Zongdong Yu, Wei Wei, Kristen M S O'Connell, and George T-J Huang

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High throughput in situ metagenomic measurement of bacterial replication at ultra-low sequencing coverage., Akintunde Emiola and Julia Oh

Reproduction: Oocytes Call, Granulosa Cells Connect., John J. Eppig

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Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions., Nicolas Floc'h, Matthew J Martin, Jonathan W Riess, Jonathan P Orme, Anna D Staniszewska, Ludovic Ménard, Maria Emanuela Cuomo, Daniel J O'Neill, Richard A Ward, M Raymond V Finlay, Darren McKerrecher, Mingshan Cheng, Daniel P Vang, Rebekah A Burich, James G. Keck, David R Gandara, Philip C Mack, and Darren A E Cross

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Gearing up to handle the mosaic nature of life in the quest for orthologs., Kristoffer Forslund, Cecile Pereira, Salvador Capella-Gutierrez, Alan Sousa da Silva, Adrian Altenhoff, Jaime Huerta-Cepas, Matthieu Muffato, Mateus Patricio, Klaas Vandepoele, Ingo Ebersberger, Judith A. Blake, Jesualdo Tomás Fernández Breis, The Quest for Orthologs Consortium, Brigitte Boeckmann, Toni Gabaldón, Erik Sonnhammer, Christophe Dessimoz, and Suzanna Lewis

The interstitium in cardiac repair: role of the immune-stromal cell interplay., Elvira Forte, Milena B Furtado, and Nadia Rosenthal

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Profiling of epidermal lipids in a mouse model of dermatitis: Identification of potential biomarkers., Jackeline Franco, Christina Ferreira, Tiago J Paschoal Sobreira, John P Sundberg, and Harm HogenEsch

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Identifying noncoding risk variants using disease-relevant gene regulatory networks., Long Gao, Yasin Uzun, Peng Gao, Bing He, Xiaoke Ma, Jiahui Wang, Shizhong Han, and Kai Tan

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DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members., Andrew M. Garrett, Andre Khalil, David O Walton, and Robert W. Burgess

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Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer., Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valérie Garès, Elizabeth L Christie, Maartje C A Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley, Thomas Mikeska, Giada V Zapparoli, Kaushalya Amarasinghe, Sean M Grimmond, John V Pearson, Nicola Waddell, Jillian Hung, Colin J R Stewart, Raghwa Sharma, Prue E Allan, Peter F Rambau, Orla McNally, Linda Mileshkin, Anne Hamilton, Sumitra Ananda, Marisa Grossi, Paul A Cohen, Yee C Leung, Robert M Rome, Philip Beale, Penny Blomfield, Michael Friedlander, Alison Brand, Alexander Dobrovic, Martin Köbel, Paul Harnett, Brad H Nelson, David D L Bowtell, and Anna deFazio

Genetic background influences susceptibility to chemotherapy-induced hematotoxicity., Daniel M. Gatti, S N Weber, N C Goodwin, F Lammert, and Gary A Churchill

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Method of derivation and differentiation of mouse embryonic stem cells generating synchronous neuronal networks., Elena V Gazina, Emma Morrisroe, Gunarathna D C Mendis, Anna E Michalska, Joseph Chen, Christian M Nefzger, Benjamin N Rollo, Christopher A Reid, Martin Pera, and Steven Petrou

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Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy., Bruno Gomes, Gregory Driessens, Derek Bartlett, Danying Cai, Sandra Cauwenberghs, Stefano Crosignani, Deepak Dalvie, Sofie Denies, Christopher P Dillon, Valeria R Fantin, Jie Guo, Marie-Claire Letellier, Wenlin Li, Karen Maegley, Reece Marillier, Nichol Miller, Romain Pirson, Virginie Rabolli, Chad Ray, Nicole Streiner, Vince R Torti, Konstantinos Tsaparikos, Benoit J Van den Eynde, Martin Wythes, Li-Chin Yao, Xianxian Zheng, Joseph Tumang, and Manfred Kraus

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Culture-independent analysis of liver abscess using nanopore sequencing., Liang Gong, Yao-Ting Huang, Chee-Hong Wong, Wen-Cheng Chao, Zong-Yen Wu, Chia-Lin Wei, and Po-Yu Liu

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Picky comprehensively detects high-resolution structural variants in nanopore long reads., Liang Gong, Chee-Hong Wong, Wei-Chung Cheng, Harianto Tjong, Francesca Menghi, Chew Yee Ngan, Edison T Liu, and Chia-Lin Wei

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"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic., Heather Gordish-Dressman, Raffaella Willmann, Laura Dalle Pazze, Arati Kreibich, Maaike van Putten, Ahlke Heydemann, Laurent P. Bogdanik, Cathleen Lutz, Kay Davies, Alexis R Demonbruen, Dongsheng Duan, David Elsey, So-Ichiro Fukada, Mahasweta Girgenrath, J Patrick Gonzalez, Miranda D Grounds, Andy Nichols, Terry Partridge, Marco Passini, Francesca Sanarica, Frederick J Schnell, Dominic J Wells, Toshifumi Yokota, Courtney S Young, Zhong Zhong, Christopher Spurney, Melissa Spencer, Annamaria De Luca, Kanneboyina Nagaraju, and Annemieke Aartsma-Rus

Physician-diagnosed eczema is an independent risk factor for incident mouse skin test sensitization in adults., Torie Grant, Jennifer Dantzer, Corinne Keet, Roger Peng, Beverly J Paigen, Mary Krevans, Karol Hagberg, Jean Curtin-Brosnan, Wayne Shreffler, and Elizabeth C Matsui

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Interaction between the microbiome and TP53 in human lung cancer., K Leigh Greathouse, James R White, Ashely J Vargas, Valery V Bliskovsky, Jessica A Beck, Natalia von Muhlinen, Eric C Polley, Elise D Bowman, Mohammed A Khan, Ana I Robles, Tomer Cooks, Bríd M Ryan, Noah Padgett, Amiran H Dzutsev, Giorgio Trinchieri, Marbin A Pineda, Sven Bilke, Paul S Meltzer, Alexis N Hokenstad, Tricia M Stickrod, Marina R Walther-Antonio, Joshua P Earl, Joshua C Mell, Jaroslaw E Krol, Sergey V Balashov, Archana S Bhat, Garth D Ehrlich, Alex Valm, Clayton Deming, Sean Conlan, Julia Oh, Julie A Segre, and Curtis C Harris

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Genomic Profiling of T-Cell Neoplasms Reveals Frequent, Allison Greenplate, Kai Wang, Rati M Tripathi, Norma Palma, Siraj M Ali, Phil J Stephens, Vincent A Miller, Yu Shyr, Yan Guo, Nishitha M Reddy, Lina Kozhaya, Derya Unutmaz, Xueyan Chen, Jonathan M Irish, and Utpal P Davé

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A human endothelial cell-based recycling assay for screening of FcRn targeted molecules., Algirdas Grevys, Jeannette Nilsen, Kine M K Sand, Muluneh B Daba, Inger Øynebråten, Malin Bern, Martin B McAdam, Stian Foss, Tilman Schlothauer, Terje E Michaelsen, Gregory J. Christianson, Derry C. Roopenian, Richard S Blumberg, Inger Sandlie, and Jan Terje Andersen

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Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice., Jing Guo, Teng Zhang, Yueshuai Guo, Tao Sun, Hui Li, Xiaoyun Zhang, Hong Yin, Guangyi Cao, Yaoxue Yin, Hao Wang, Lanying Shi, Xuejiang Guo, Jiahao Sha, John J. Eppig, and You-Qiang Su

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Classification, Ontology, and Precision Medicine., Melissa A Haendel, Christopher G Chute, and Peter N Robinson

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Comprehensive Endocrine-Metabolic Evaluation of Patients With Alström Syndrome Compared With BMI-Matched Controls., Joan C Han, Daniela P Reyes-Capo, Chia-Ying Liu, James C Reynolds, Evrim Turkbey, Ismail Baris Turkbey, Joy Bryant, Jan D Marshall, Juergen K. Naggert, William A Gahl, Jack A Yanovski, and Meral Gunay-Aygun

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Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice., Jeffrey M. Harder, Pete A. Williams, Ileana Soto, Nicole E Foxworth, Kimberly A Fernandes, Nelson F Freeburg, Richard T Libby, and Simon W M John

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Increased Reactive Oxygen Species and Cell Cycle Defects Contribute to Anemia in the RASA3 Mutant Mouse Model s, Emily S Hartman, Elena C Brindley, Julien Papoin, Steven L. Ciciotte, Yue Zhao, Luanne L. Peters, and Lionel Blanc

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Genomic Profiling of Two Histologically Distinct Rare Urothelial Cancers in a Clinical Setting to Identify Potential Therapeutic Options for Treatment and Management of Disease., Andrew N Hesse, William Fabricius, Christian A Thomas, Ramesh Gaindh, Robert Christman, Pavalan Selvam, Matthew Prego, Gregory Lewis, Jasmina Uvalic, Daniel Bergeron, Shelbi Burns, Bridgette Sisson, Kevin Kelly, Jens Rueter, and Honey V Reddi

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Meta-analysis of the lung microbiota in pulmonary tuberculosis., Bo-Young Hong, Joseph N Paulson, O Colin Stine, George M. Weinstock, and Jorge L Cervantes

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ADAM17 is essential for ectodomain shedding of the EGF-receptor ligand amphiregulin., Vishnu Hosur, Michelle L Farley, Lisa M. Burzenski, Leonard D. Shultz, and Michael V. Wiles

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RHBDF2-regulated growth factor signaling in a rare human disease tylosis with esophageal cancer: What can we learn from murine models?, Vishnu Hosur, Benjamin E. Low, Michelle L Farley, Lisa M. Burzenski, Leonard D. Shultz, and Michael V. Wiles

Model organism data evolving in support of translational medicine., Douglas G Howe, Judith A. Blake, Yvonne M Bradford, Carol J Bult, Brian R Calvi, Stacia R Engel, James A. Kadin, Thomas C Kaufman, Ranjana Kishore, Stanley J F Laulederkind, Suzanna E Lewis, Sierra A T Moxon, Joel E Richardson, and Cynthia Smith

Genetic Models of Macrophage Depletion., Li Hua, Jiayuan Shi, Leonard D. Shultz, and Guangwen Ren

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RACIPE: a computational tool for modeling gene regulatory circuits using randomization., Bin Huang, Dongya Jia, Jingchen Feng, Herbert Levine, José N Onuchic, and Mingyang Lu

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Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources., Liang-Chin Huang, Karen E Ross, Timothy R Baffi, Harold J. Drabkin, Krzysztof J Kochut, Zheng Ruan, Peter D'Eustachio, Daniel McSkimming, Cecilia Arighi, Chuming Chen, Darren A Natale, Cynthia Smith, Pascale Gaudet, Alexandra C Newton, Cathy Wu, and Natarajan Kannan

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Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice., Jianjun Hu, Fengyun Sun, and Mary Ann Handel

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TumorFusions: an integrative resource for cancer-associated transcript fusions., Xin Hu, Qianghu Wang, Ming Tang, Floris P Barthel, Samirkumar B Amin, Kosuke Yoshihara, Frederick M Lang, Emmanuel Martinez-Ledesma, Soo Hyun Lee, Siyuan Zheng, and Roel G W Verhaak

Depletion of SMC5/6 sensitizes male germ cells to DNA damage., G Hwang, D E Verver, Mary Ann Handel, G Hamer, and P W Jordan

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Development, Function, and Clinical Significance of Plasmacytoid Dendritic Cells in Chronic Myeloid Leukemia., Sabrina Inselmann, Ying Wang, Susanne Saussele, Lea Fritz, Christin Schütz, Magdalena Huber, Simone Liebler, Thomas Ernst, Dali Cai, Sarah Botschek, Cornelia Brendel, Raffaele A Calogero, Dinko Pavlinic, Vladimir Benes, Edison T Liu, Andreas Neubauer, Andreas Hochhaus, and Andreas Burchert

Nondestructive, label-free characterization of mechanical microheterogeneity in biomimetic materials., Devina Jaiswal, Min D Tang-Schomer, Disha Sood, David L Kaplan, and Kazunori Hoshino

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Role of Alström syndrome 1 in the regulation of blood pressure and renal function., Ankita Bachhawat Jaykumar, Paulo S Caceres, Keyona N King-Medina, Tang-Dong Liao, Indrani Datta, Dipak Maskey, Juergen K. Naggert, Mariela Mendez, William H Beierwaltes, and Pablo A Ortiz

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DNA methylomes of bovine gametes and in vivo produced preimplantation embryos., Zongliang Jiang, Jianan Lin, Hong Dong, Xinbao Zheng, Sadie L Marjani, Jingyue Duan, Zhengqing Ouyang, Jingbo Chen, and Xiuchun Cindy Tian

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Deletion of a Long-Range, Kenneth R. Johnson, Leona H. Gagnon, Cong Tian, Chantal M. Longo-Guess, Benjamin E. Low, Michael V. Wiles, and Amy E Kiernan

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Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice., Kenneth R. Johnson, Leona H. Gagnon, Cong Tian, Chantal M. Longo-Guess, Benjamin E. Low, Michael V. Wiles, and Amy E Kiernan

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Reproducibility and replicability of rodent phenotyping in preclinical studies., Neri Kafkafi, Joseph Agassi, Elissa J Chesler, John C Crabbe, Wim E Crusio, David Eilam, Robert Gerlai, Ilan Golani, Alex Gomez-Marin, Ruth Heller, Fuad Iraqi, Iman Jaljuli, Natasha A Karp, Hugh Morgan, George Nicholson, Donald W Pfaff, S Helene Richter, Philip B Stark, Oliver Stiedl, Victoria Stodden, Lisa M Tarantino, Valter Tucci, William Valdar, Robert W Williams, Hanno Würbel, and Yoav Benjamini

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Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats., Gregory R Keele, Jeremy W Prokop, Hong He, Katie Holl, John Littrell, Aaron Deal, Sanja Francic, Leilei Cui, Daniel M. Gatti, Karl W Broman, Michael Tschannen, Shirng-Wern Tsaih, Maie Zagloul, Yunjung Kim, Brittany Baur, Joseph Fox, Melanie Robinson, Shawn Levy, Michael J Flister, Richard Mott, William Valdar, and Leah C Solberg Woods

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Genetic Drivers of Pancreatic Islet Function., Mark P Keller, Daniel M. Gatti, Kathryn L Schueler, Mary E Rabaglia, Donnie S Stapleton, Petr Simecek, Matthew J Vincent, Sadie Allen, Aimee Teo Broman, Rhonda Bacher, Christina Kendziorski, Karl W Broman, Brian S Yandell, Gary A Churchill, and Alan D Attie