Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota.
Document Type
Article
Publication Date
6-5-2018
JAX Source
Cell Metab 2018 Jun 5; 27(6):1222-1235.
Volume
27
Issue
6
First Page
1222
Last Page
1235
ISSN
1932-7420
PMID
29874567
DOI
https://doi.org/10.1016/j.cmet.2018.05.006
Grant
NS102633
Abstract
Multiple sclerosis (MS) is more common in western countries with diet being a potential contributing factor. Here we show that intermittent fasting (IF) ameliorated clinical course and pathology of the MS model, experimental autoimmune encephalomyelitis (EAE). IF led to increased gut bacteria richness, enrichment of the Lactobacillaceae, Bacteroidaceae, and Prevotellaceae families and enhanced antioxidative microbial metabolic pathways. IF altered T cells in the gut with a reduction of IL-17 producing T cells and an increase in regulatory T cells. Fecal microbiome transplantation from mice on IF ameliorated EAE in immunized recipient mice on a normal diet, suggesting that IF effects are at least partially mediated by the gut flora. In a pilot clinical trial in MS patients, intermittent energy restriction altered blood adipokines and the gut flora resembling protective changes observed in mice. In conclusion, IF has potent immunomodulatory effects that are at least partially mediated by the gut microbiome. Cell Metab 2018 Jun 5; 27(6):1222-1235.
Recommended Citation
Cignarella F,
Cantoni C,
Ghezzi L,
Salter A,
Dorsett Y,
Chen L,
Phillips D,
Weinstock GM,
Fontana L,
Cross A,
Zhou Y,
Piccio L.
Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota. Cell Metab 2018 Jun 5; 27(6):1222-1235.