Submissions from 2018
Evaluation of exome filtering techniques for the analysis of clinically relevant genes., Kristin D Kernohan, Taila Hartley, Najmeh Alirezaie, Care4Rare Canada Consortium, Peter N Robinson, David A Dyment, and Kym M Boycott
Transcriptional profiling of murine osteoblast differentiation based on RNA-seq expression analyses., Layal Abo Khayal, Johannes Grünhagen, Ivo Provazník, Stefan Mundlos, Uwe Kornak, Peter N Robinson, and Claus-Eric Ott
Type 2 Diabetes-Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets., Shubham Khetan, Romy Kursawe, Ahrim Youn, Nathan Lawlor, Alexandria Jillette, Eladio J Marquez, Duygu Ucar, and Michael L. Stitzel
High-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts., Hyunsoo Kim, Pooja A Kumar, Francesca Menghi, Javad Noorbakhsh, Eliza Cerveira, Mallory Ryan, Qihui Zhu, Guruprasad Ananda, Joshy George, Henry C Chen, Susan Mockus, Chengsheng Zhang, Yan Yang, James G. Keck, Radha Krishna Murthy Karuturi, Carol J Bult, Charles Lee, Edison Liu, and Jeffrey H Chuang
Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest-Old Population., Yeo Jin Kim, Hyun Soo Kim, and Young Rok Seo
Characterization of glycosylphosphatidylinositol biosynthesis defects by clinical features, flow cytometry, and automated image analysis., Alexej Knaus, Jean Tori Pantel, Manuela Pendziwiat, Nurulhuda Hajjir, Max Zhao, Tzung-Chien Hsieh, Max Schubach, Yaron Gurovich, Nicole Fleischer, Marten Jäger, Sebastian Köhler, Hiltrud Muhle, Christian Korff, Rikke S Møller, Allan Bayat, Patrick Calvas, Nicolas Chassaing, Hannah Warren, Steven Skinner, Raymond Louie, Christina Evers, Marc Bohn, Hans-Jürgen Christen, Myrthe van den Born, Ewa Obersztyn, Agnieszka Charzewska, Milda Endziniene, Fanny Kortüm, Natasha Brown, Peter N Robinson, Helenius J Schelhaas, Yvonne Weber, Ingo Helbig, Stefan Mundlos, Denise Horn, and Peter M Krawitz
Role of noise and parametric variation in the dynamics of gene regulatory circuits., Vivek Kohar and Mingyang Lu
The Impact of Adherens and Tight Junctions on Physiological Function and Pathological Changes in the Retina., Yang Kong, Juergen K. Naggert, and Patsy M. Nishina
A FRMD4B variant suppresses dysplastic photoreceptor lesions in models of enhanced S-cone syndrome and of Nrl deficiency., Yang Kong, Lihong Zhao, Jeremy R. Charette, Wanda L. Hicks, Lisa Stone, Patsy M. Nishina, and Juergen K. Naggert
A Systems Biology Approach to Understanding the Pathophysiology of High-Grade Serous Ovarian Cancer: Focus on Iron and Fatty Acid Metabolism., Anna Konstorum, Miranda L Lynch, Suzy V Torti, Frank M Torti, and Reinhard C Laubenbacher
ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells., Jocelyn F Krey, Rachel A Dumont, Philip A Wilmarth, Larry L David, Kenneth R. Johnson, and Peter G Barr-Gillespie
Determination of T Follicular Helper Cell Fate by Dendritic Cells., Jayendra Kumar Krishnaswamy, Samuel Alsén, Ulf Yrlid, Stephanie C Eisenbarth, and Adam Williams
Serial immunological parameters in a phase II trial of exemestane and low-dose oral cyclophosphamide in advanced hormone receptor-positive breast cancer., Maryann Kwa, Xiaochun Li, Yelena Novik, Ruth Oratz, Komal Jhaveri, Jennifer Wu, Ping Gu, Marleen Meyers, Franco Muggia, James Speyer, Alyssa Iwano, Maryam Bonakdar, Lina Kozhaya, Ece Tavukcuoglu, Bahar Budan, Roy Raad, Judith D Goldberg, Derya Unutmaz, and Sylvia Adams
A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression., Ina Kycia, Brooke N Wolford, Jeroen R Huyghe, Christian Fuchsberger, Swarooparani Vadlamudi, Romy Kursawe, Ryan P Welch, Ricardo d'Oliveira Albanus, Asli Uyar, Shubham Khetan, Nathan Lawlor, Mohan Bolisetty, Anubhuti Mathur, Johanna Kuusisto, Markku Laakso, Duygu Ucar, Karen L Mohlke, Michael Boehnke, Francis S Collins, Stephen C J Parker, and Michael L. Stitzel
The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4)., Kory J Lavine, Alexander R Pinto, Slava Epelman, Benjamin J Kopecky, Xavier Clemente-Casares, James Godwin, Nadia Rosenthal, and Jason C Kovacic
Mouse Genome Informatics (MGI) Is the International Resource for Information on the Laboratory Mouse., MeiYee Law and David R. Shaw
Detection of correlated hidden factors from single cell transcriptomes using Iteratively Adjusted-SVA (IA-SVA)., Donghyung Lee, Anthony Cheng, Nathan Lawlor, Mohan Bolisetty, and Duygu Ucar
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy., Jin-Ku Lee, Zhaoqi Liu, Jason K Sa, Sang Shin, Jiguang Wang, Mykola Bordyuh, Hee Jin Cho, Oliver Elliott, Timothy Chu, Seung Won Choi, Daniel I S Rosenbloom, In-Hee Lee, Yong Jae Shin, Hyun Ju Kang, Donggeon Kim, Sun Young Kim, Moon-Hee Sim, Jusun Kim, Taehyang Lee, Yun Jee Seo, Hyemi Shin, Mijeong Lee, Sung Heon Kim, Yong-Jun Kwon, Jeong-Woo Oh, Minsuk Song, Misuk Kim, Doo-Sik Kong, Jung Won Choi, Ho Jun Seol, Jung-Il Lee, Seung Tae Kim, Joon Oh Park, Kyoung-Mee Kim, Sang-Yong Song, Jeong-Won Lee, Hee-Cheol Kim, Jeong Eon Lee, Min Gew Choi, Sung Wook Seo, Young Mog Shim, Jae Ill Zo, Byong Chang Jeong, Yeup Yoon, Gyu Ha Ryu, Nayoung K D Kim, Joon Seol Bae, Woong-Yang Park, Jeongwu Lee, Roel G W Verhaak, Antonio Iavarone, Jeeyun Lee, Raul Rabadan, and Do-Hyun Nam
Cell Labeling with Magneto-Endosymbionts and the Dissection of the Subcellular Location, Fate, and Host Cell Interactions., Kayla R Lee, Abdul Wakeel, Papia Chakraborty, Chandler S Foote, Lauren Kajiura, Joyce C Barrozo, Andrea C Chan, Alexey V Bazarov, Ryan Spitler, Peter M Kutny, James M. Denegre, Robert A. Taft, Joachim Seemann, Bradley W Rice, Christopher H Contag, Brian K Rutt, and Caleb B Bell
Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches., Tiffany Leidy-Davis, Kai Cheng, Leslie Goodwin, Judith L Morgan, Wen Chun Juan, Xavier Roca, S Tiong Ong, and David E. Bergstrom
ORAI1 mutations abolishing store-operated Ca, Jayson Lian, Mario Cuk, Sascha Kahlfuss, Lina Kozhaya, Martin Vaeth, Frédéric Rieux-Laucat, Capucine Picard, Melina J Benson, Antonia Jakovcevic, Karmen Bilic, Iva Martinac, Peter Stathopulos, Imre Kacskovics, Thomas Vraetz, Carsten Speckmann, Stephan Ehl, Thomas Issekutz, Derya Unutmaz, and Stefan Feske
Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates., Fang Li, Ruijuan Xu, Benjamin E. Low, Chih-Li Lin, Monica Garcia-Barros, Jennifer Schrandt, Izolda Mileva, Ashley Snider, Catherine K Luo, Xian-Cheng Jiang, Ming-Song Li, Yusuf A Hannun, Lina M Obeid, Michael V. Wiles, and Cungui Mao
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci., Jingtao Lilue, Anthony G Doran, Ian T Fiddes, Monica Abrudan, Joel Armstrong, Ruth Bennett, William Chow, Joanna Collins, Stephan Collins, Anne M Czechanski, Petr Danecek, Mark Diekhans, Dirk-Dominik Dolle, Matt Dunn, Richard Durbin, Dent Earl, Anne Ferguson-Smith, Paul Flicek, Jonathan Flint, Adam Frankish, Beiyuan Fu, Mark Gerstein, James Gilbert, Leo Goodstadt, Jennifer Harrow, Kerstin Howe, Ximena Ibarra-Soria, Mikhail Kolmogorov, Chris J Lelliott, Darren W Logan, Jane Loveland, Clayton E Mathews, Richard Mott, Paul Muir, Stefanie Nachtweide, Fabio C P Navarro, Duncan T Odom, Naomi Park, Sarah Pelan, Son K Pham, Mike Quail, Laura Reinholdt, Lars Romoth, Lesley Shirley, Cristina Sisu, Marcela Sjoberg-Herrera, Mario Stanke, Charles Steward, Mark Thomas, Glen Threadgold, David Thybert, James Torrance, Kim Wong, Jonathan Wood, Binnaz Yalcin, Fengtang Yang, David J Adams, Benedict Paten, and Thomas M Keane
Digestion-ligation-only Hi-C is an efficient and cost-effective method for chromosome conformation capture., Da Lin, Ping Hong, Siheng Zhang, Weize Xu, Muhammad Jamal, Keji Yan, Yingying Lei, Liang Li, Yijun Ruan, Zhen F Fu, Guoliang Li, and Gang Cao
Etidronate prevents, but does not reverse, ectopic mineralization in a mouse model of pseudoxanthoma elasticum (, Qiaoli Li, Joshua Kingman, John P Sundberg, Michael A Levine, and Jouni Uitto
Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model., Qilai Long, Tzu-Yin Lin, Yee Huang, Xiaocen Li, Ai-Hong Ma, Hongyong Zhang, Randy Carney, Susan Airhart, Kit S Lam, Ralph W deVere White, Chong-Xian Pan, and Yuanpei Li
Improving Interpretation of Cardiac Phenotypes and Enhancing Discovery With Expanded Knowledge in the Gene Ontology., Ruth C Lovering, Paola Roncaglia, Douglas G Howe, Stanley J F Laulederkind, Varsha K Khodiyar, Tanya Z Berardini, Susan Tweedie, Rebecca E Foulger, David Osumi-Sutherland, Nancy H Campbell, Rachael P Huntley, Philippa J Talmud, Judith A. Blake, Ross Breckenridge, Paul R Riley, Pier D Lambiase, Perry M Elliott, Lucie Clapp, Andrew Tinker, and David P. Hill
Mouse models of ALS: Past, present and future., Cathleen Lutz
Triple Vectors Expand AAV Transfer Capacity in the Retina., Andrea Maddalena, Patrizia Tornabene, Paola Tiberi, Renato Minopoli, Anna Manfredi, Margherita Mutarelli, Settimio Rossi, Francesca Simonelli, Juergen K. Naggert, Davide Cacchiarelli, and Alberto Auricchio
Harmonising phenomics information for a better interoperability in the rare disease field., Sylvie Maiella, Annie Olry, Marc Hanauer, Valérie Lanneau, Halima Lourghi, Bruno Donadille, Charlotte Rodwell, Sebastian Köhler, Dominik Seelow, Simon Jupp, Helen Parkinson, Tudor Groza, Michael Brudno, Peter N Robinson, and Ana Rath
Methodology, Criteria, and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts., Laura A Marlow, Stephen D Rohl, James L Miller, Jeffery A Knauf, James A Fagin, Mabel Ryder, Dragana Milosevic, Brian C Netzel, Stefan K Grebe, Honey V Reddi, Robert C Smallridge, and John A Copland
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours., Xiaotu Ma, Yu Liu, Yanling Liu, Ludmil B Alexandrov, Michael N Edmonson, Charles Gawad, Xin Zhou, Yongjin Li, Michael C Rusch, John Easton, Robert Huether, Veronica Gonzalez-Pena, Mark R Wilkinson, Leandro C Hermida, Sean Davis, Edgar Sioson, Stanley Pounds, Xueyuan Cao, Rhonda E Ries, Zhaoming Wang, Xiang Chen, Li Dong, Sharon J Diskin, Malcolm A Smith, Jaime M Guidry Auvil, Paul S Meltzer, Ching C Lau, Elizabeth J Perlman, John M Maris, Soheil Meshinchi, Stephen P Hunger, Daniela S Gerhard, and Jinghui Zhang
Low Peripheral T Follicular Helper Cells in Perinatally HIV-Infected Children Correlate With Advancing HIV Disease., Bret McCarty, Mussa Mwamzuka, Fatma Marshed, Matthew Generoso, Patricia Alvarez, Tiina Ilmet, Adam Kravietz, Aabid Ahmed, William Borkowsky, Derya Unutmaz, and Alka Khaitan
The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations., Francesca Menghi, Floris P Barthel, Vinod Yadav, Ming Tang, Bo Ji, Zhonghui Tang, Gregory W. Carter, Yijun Ruan, Ralph Scully, Roel G W Verhaak, Jos Jonkers, and Edison T Liu
Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through, Tapan Kumar Mistri, Wibowo Arindrarto, Wei Ping Ng, Choayang Wang, Leng Hiong Lim, Lili Sun, Ian Chambers, Thorsten Wohland, and Paul Robson
Acclimation and Institutionalization of the Mouse Microbiota Following Transportation., Dan R Montonye, Aaron C Ericsson, Susheel B Busi, Cathleen Lutz, Keegan Wardwell, and Craig L Franklin
Identification of genes required for eye development by high-throughput screening of mouse knockouts., Bret A Moore, Brian C Leonard, Lionel Sebbag, Sydney G Edwards, Ann Cooper, Denise M Imai, Ewan Straiton, Luis Santos, Christopher Reilly, Stephen M Griffey, Lynette Bower, David Clary, Jeremy Mason, Michel J Roux, Hamid Meziane, Yann Herault, Colin McKerlie, Ann M Flenniken, Lauryl M J Nutter, Zorana Berberovic, Celeste Owen, Susan Newbigging, Hibret Adissu, Mohammed Eskandarian, Chih-Wei Hsu, Sowmya Kalaga, Uchechukwu Udensi, Chinwe Asomugha, Ritu Bohat, Juan J Gallegos, John R Seavitt, Jason D Heaney, Arthur L Beaudet, Mary E Dickinson, Monica J Justice, Vivek M. Philip, Vivek Kumar, Karen L. Svenson, Robert E Braun, Sara Wells, Heather Cater, Michelle Stewart, Sharon Clementson-Mobbs, Russell Joynson, Xiang Gao, Tomohiro Suzuki, Shigeharu Wakana, Damian Smedley, J K Seong, Glauco Tocchini-Valentini, Mark Moore, Colin Fletcher, Natasha Karp, Ramiro Ramirez-Solis, Jacqueline K White, Martin Hrabe de Angelis, Wolfgang Wurst, Sara M Thomasy, Paul Flicek, Helen Parkinson, Steve D M Brown, Terrence F Meehan, Patsy M. Nishina, Stephen A. Murray, Mark P. Krebs, Ann-Marie Mallon, K C Kent Lloyd, Christopher J Murphy, and Ala Moshiri
Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy., Zhongying Mo, Xiaobei Zhao, Huaqing Liu, Qinghua Hu, Xu-Qiao Chen, Jessica Pham, Na Wei, Ze Liu, Jiadong Zhou, Robert W. Burgess, Samuel L Pfaff, C Thomas Caskey, Chengbiao Wu, Ge Bai, and Xiang-Lei Yang
The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation., Violeta Muñoz-Fuentes, Pilar Cacheiro, Terrence F Meehan, Juan Antonio Aguilar-Pimentel, Steve D M Brown, Ann M Flenniken, Paul Flicek, Antonella Galli, Hamed Haseli Mashhadi, Martin Hrabě de Angelis, Jong Kyoung Kim, K C Kent Lloyd, Colin McKerlie, Hugh Morgan, Stephen A. Murray, Lauryl M J Nutter, Patrick T Reilly, John R Seavitt, Je Kyung Seong, Michelle Simon, Hannah Wardle-Jones, Ann-Marie Mallon, Damian Smedley, and Helen E Parkinson
The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans., Mansa A Munshi, Justin M Gardin, Ashutosh Singh, Chiara Luberto, Robert Rieger, Tejas Bouklas, Bettina C Fries, and Maurizio Del Poeta
The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection., Andrea M Muscat, Nicholas C Wong, Katharine J Drummond, Elizabeth M Algar, Mustafa Khasraw, Roel G W Verhaak, Kathryn Field, Mark A Rosenthal, and David M Ashley
A commensal strain of Staphylococcus epidermidis protects against skin neoplasia., Teruaki Nakatsuji, Tiffany H Chen, Anna M Butcher, Lynnie L Trzoss, Sang-Jip Nam, Karina T Shirakawa, Wei Zhou, Julia Oh, Michael Otto, William Fenical, and Richard L Gallo
Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis., Danitza Nébor, Joel H. Graber, Steven L. Ciciotte, Ray F. Robledo, Julien Papoin, Emily Hartman, Kevin R Gillinder, Andrew C Perkins, James J Bieker, Lionel Blanc, and Luanne L. Peters
Inferring Transmission Histories of Rare Alleles in Population-Scale Genealogies., Dominic Nelson, Claudia Moreau, Marianne de Vriendt, Yixiao Zeng, Christoph Preuss, Hélène Vézina, Emmanuel Milot, Gregor Andelfinger, Damian Labuda, and Simon Gravel
Synthetic Peptide CK2.3 Enhances Bone Mineral Density in Senile Mice., John Nguyen, Hilary Weidner, Lora M Schell, Linda Sequeira, Ryan Kabrick, Saurabh Dharmadhikari, Harold Coombs, Randall L Duncan, Liyun Wang, and Anja Nohe
Animal models for evaluation of albumin-based therapeutics, Jeannette Nilsen, Inger Sandlie, Derry C. Roopenian, and Jan Terje Andersen
Distribution-based measures of tumor heterogeneity are sensitive to mutation calling and lack strong clinical predictive power., Javad Noorbakhsh, Hyunsoo Kim, Sandeep Namburi, and Jeffrey H Chuang
Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo"., Lauryl M J Nutter, Jason D Heaney, K C Kent Lloyd, Stephen A. Murray, John R Seavitt, William C Skarnes, Lydia Teboul, Steve D M Brown, and Mark Moore
Identification of a Novel microRNA Profile in Pediatric Cancer Patients treated with Anthracycline Chemotherapy., Kelsie E Oatmen, Olga H Toro-Salazar, Kristine Hauser, Kia N Zellars, Kathryn C Mason, Kan Hor, Eileen Gillan, Caroline J Zeiss, Daniel M. Gatti, and Francis G Spinale
Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies., Lori L O'Brien, Qiuyu Guo, Emad Bahrami-Samani, Joo-Seop Park, Sean M Hasso, Young-Jin Lee, Alan Fang, Albert D Kim, Jinjin Guo, Trudy M Hong, Kevin A Peterson, Scott Lozanoff, Ramya Raviram, Bing Ren, Ben Fogelgren, Andrew D Smith, Anton Valouev, and Andrew P McMahon
DDR: efficient computational method to predict drug-target interactions using graph mining and machine learning approaches., Rawan S Olayan, Haitham Ashoor, and Vladimir B Bajic
Mouse Models for Cancer Immunotherapy Research., Brian Olson, Yadi Li, Yu Lin, Edison T Liu, and Akash Patnaik
Immunodeficiency in a Child with Alström Syndrome., Taha Resid Ozdemir, Neslihan Edeer Karaca, Jan Davis Marshall, Necil Kutukculer, Guzide Aksu, Riza Koksal Ozgul, Aysegul Ozanturk, Esra Isik, Bilcag Akgun, Hamiyet Hekimci Ozdemir, Sukran Darcan, Ferda Ozkinay, and Ozgur Cogulu
Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function., Laura Padrón-Barthe, María Villalba-Orero, Jesús M Gómez-Salinero, Rebeca Acín-Pérez, Sara Cogliati, Marina López-Olañeta, Paula Ortiz-Sánchez, Elena Bonzón-Kulichenko, Jesús Vázquez, Pablo García-Pavía, Nadia Rosenthal, José Antonio Enríquez, and Enrique Lara-Pezzi
PRDM9 and Its Role in Genetic Recombination., Kenneth Paigen and Petko M. Petkov
Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition., Mona Panahi, Angelos Papanikolaou, Azam Torabi, Ji-Gang Zhang, Habib Khan, Ali Vazir, Muneer G. Hasham, John G F Cleland, Nadia Rosenthal, Sian E Harding, and Susanne Sattler
Towards smart self-clearing glaucoma drainage device., Hyunsu Park, Amir Hossein Rafiee, Simon W M John, Arezoo M. Ardekani, and Hyowon Lee
An important role for periplasmic storage in Pseudomonas aeruginosa copper homeostasis revealed by a combined experimental and computational modeling study., Jignesh H Parmar, Julia Quintana, David Ramírez, Reinhard Laubenbacher, José M Argüello, and Pedro Mendes
Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error., Seyyedhassan Paylakhi, Cassandre Labelle-Dumais, Nicholas G Tolman, Michael A Sellarole, Yusef Seymens, Joseph Saunders, Hesham Lakosha, Wilhelmine N de Vries, Andrew C Orr, Piotr Topilko, Simon W M John, and K Saidas Nair
Developmental constraint through negative pleiotropy in the zygomatic arch., Christopher J Percival, Rebecca Green, Charles C Roseman, Daniel M. Gatti, Judy Morgan, Stephen A. Murray, Leah Rae Donahue, Jessica M Mayeux, K Michael Pollard, Kunjie Hua, Daniel Pomp, Ralph Marcucio, and Benedikt Hallgrímsson
Integrative Personal Omics Profiles during Periods of Weight Gain and Loss., Brian D Piening, Wenyu Zhou, Kévin Contrepois, Hannes Röst, Gucci Jijuan Gu Urban, Tejaswini Mishra, Blake M Hanson, Eddy J Bautista, Shana Leopold, Christine Y Yeh, Daniel Spakowicz, Imon Banerjee, Cynthia Chen, Kimberly Kukurba, Dalia Perelman, Colleen Craig, Elizabeth Colbert, Denis Salins, Shannon Rego, Sunjae Lee, Cheng Zhang, Jessica Wheeler, M Reza Sailani, Liang Liang, Charles Abbott, Mark Gerstein, Adil Mardinoglu, Ulf Smith, Daniel L Rubin, Sharon Pitteri, Erica Sodergren Weinstock, Tracey L McLaughlin, George M. Weinstock, and Michael P Snyder
A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice., Maximiliano Presa, Jeremy Racine, Jennifer R Dwyer, Deanna Lamont, Jeremy Ratiu, Vishal Kumar Sarsani, Yi-Guang Chen, Aron Geurts, Ingo Schmitz, Timothy M Stearns, Jennifer Allocco, Harry Chapman, and David V. Serreze
Consensus coding sequence (CCDS) database: a standardized set of human and mouse protein-coding regions supported by expert curation., Shashikant Pujar, Nuala A O'Leary, Catherine M Farrell, Jane E Loveland, Jonathan M Mudge, Craig Wallin, Carlos G Girón, Mark Diekhans, If Barnes, Ruth Bennett, Andrew E Berry, Eric Cox, Claire Davidson, Tamara Goldfarb, Jose M Gonzalez, Toby Hunt, John Jackson, Vinita Joardar, Mike P Kay, Vamsi K Kodali, Fergal J Martin, Monica McAndrews, Kelly M McGarvey, Michael Murphy, Bhanu Rajput, Sanjida H Rangwala, Lillian D Riddick, Ruth L Seal, Marie-Marthe Suner, David Webb, Sophia Zhu, Bronwen L Aken, Elspeth A Bruford, Carol J Bult, Adam Frankish, Terence Murphy, and Kim D Pruitt
Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During Murine Embryogenesis Does Not Involve miRNA Biogenesis., Sri Ramulu N Pullagura, F William Buaas, Nichelle Gray, Lindsey C Krening, Anuj Srivastava, and Robert E Braun
Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development., Jeremy Racine, Isabel Stewart, Jeremy Ratiu, Gregory J. Christianson, Emily Lowell, Kelsay Helm, Jennifer Allocco, Richard S. Maser, Yi-Guang Chen, Cathleen Lutz, Derry C. Roopenian, Jennifer Schloss, Teresa P DiLorenzo, and David V. Serreze
Hierarchical analysis of RNA-seq reads improves the accuracy of allele-specific expression., Narayanan Raghupathy, Kwangbom Choi, Matthew J Vincent, Glen L Beane, Keith Sheppard, Steven C. Munger, Ron Korstanje, Fernando Pardo-Manual de Villena, and Gary Churchill
Direct-to-consumer genetic testing for breast cancer risk., Kate Reed and Emily A Edelman
Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Lepr, Peter C. Reifsnyder, Sergey Ryzhov, Kevin Flurkey, Rea P Anunciado-Koza, Ian Mills, David E Harrison, and Robert A Koza
Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes., Bruce A Rheaume, Amyeo Jereen, Mohan Bolisetty, Muhammad S Sajid, Yue Yang, Kathleen Renna, Lili Sun, Paul Robson, and Ephraim F Trakhtenberg
Corneocyte proteomics: Applications to skin biology and dermatology., Robert H Rice, Blythe P Durbin-Johnson, Selena M Mann, Michelle Salemi, Shiro Urayama, David M Rocke, Brett S Phinney, and John P Sundberg
Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice., Wolfgang F Richter, Gregory J. Christianson, Nicolas Frances, Hans Peter Grimm, Gabriele Proetzel, and Derry C. Roopenian
An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates the "Perfect Storm"., Laura J Rojas, George M. Weinstock, Elsa De La Cadena, Lorena Diaz, Rafael Rios, Blake M Hanson, Joseph S Brown, Purva Vats, Daniel S Phillips, Hoan Nguyen, Kristine M Hujer, Adriana Correa, Mark D Adams, Federico Perez, Erica Sodergren Weinstock, Apurva Narechania, Paul J Planet, Maria V Villegas, Robert A Bonomo, and Cesar A Arias
Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia., Bruce A Rosa, Taniawati Supali, Lincoln Gankpala, Yenny Djuardi, Erliyani Sartono, Yanjiao Zhou, Kerstin Fischer, John Martin, Rahul Tyagi, Fatorma K Bolay, Peter U Fischer, Maria Yazdanbakhsh, and Makedonka Mitreva
Screening Gene Knockout Mice for Variation in Bone Mass: Analysis by μCT and Histomorphometry., David W Rowe, Douglas J Adams, Seung-Hyun Hong, Caibin Zhang, Dong-Guk Shin, C Renata Rydzik, Li Chen, Zhihua Wu, Gaven Garland, Dana A Godfrey, John P Sundberg, and Cheryl Ackert-Bicknell
Identification of genetic elements in metabolism by high-throughput mouse phenotyping., Jan Rozman, Birgit Rathkolb, Manuela A Oestereicher, Christine Schütt, Aakash Chavan Ravindranath, Stefanie Leuchtenberger, Sapna Sharma, Martin Kistler, Monja Willershäuser, Robert Brommage, Terrence F Meehan, Jeremy Mason, Hamed Haselimashhadi, Tertius Hough, Ann-Marie Mallon, Sara Wells, Luis Santos, Christopher J Lelliott, Jacqueline K White, Tania Sorg, Marie-France Champy, Lynette R Bower, Corey L Reynolds, Ann M Flenniken, Stephen A. Murray, Lauryl M J Nutter, Karen L. Svenson, David West, Glauco P Tocchini-Valentini, Arthur L Beaudet, Fatima Bosch, Robert E Braun, Michael S Dobbie, Xiang Gao, Yann Herault, Ala Moshiri, Bret A Moore, K C Kent Lloyd, Colin McKerlie, Hiroshi Masuya, Nobuhiko Tanaka, Paul Flicek, Helen E Parkinson, Radislav Sedlacek, Je Kyung Seong, Chi-Kuang Leo Wang, Mark Moore, Steve D Brown, Matthias H Tschöp, Wolfgang Wurst, Martin Klingenspor, Eckhard Wolf, Johannes Beckers, Fausto Machicao, Andreas Peter, Harald Staiger, Hans-Ulrich Häring, Harald Grallert, Monica Campillos, Holger Maier, Helmut Fuchs, Valerie Gailus-Durner, Thomas Werner, and Martin Hrabe de Angelis
Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice., Katya B Rubinow, Barbara Houston, Shari Wang, Leela Goodspeed, Kayoko Ogimoto, Gregory J Morton, Christopher McCarty, Robert E Braun, and Stephanie T Page
Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes., Ivan Rusyn, Steven R Kleeberger, Kimberly A McAllister, John E French, and Karen L. Svenson
Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations., Sarah C Rutherford, Angela A Fachel, Sheng Li, Seema Sawh, Ashlesha Muley, Jennifer Ishii, Ashish Saxena, Pilar M Dominguez, Eloisi Caldas Lopes, Xabier Agirre, Nyasha Chambwe, Fabian Correa, Yanwen Jiang, Kristy L Richards, Doron Betel, and Rita Shaknovich
A prospective microbiome-wide association study of food sensitization and food allergy in early childhood., Jessica H Savage, Kathleen A Lee-Sarwar, Joanne Sordillo, Supinda Bunyavanich, Yanjiao Zhou, George O'Connor, Megan Sandel, Leonard B Bacharier, Robert Zeiger, Erica Sodergren Weinstock, George M. Weinstock, Diane R Gold, Scott T Weiss, and Augusto A Litonjua
Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli., Lisa M Schechter, David P Creely, Cherilyn D Garner, Dee Shortridge, Hoan Nguyen, Lei Chen, Blake M Hanson, Erica Sodergren Weinstock, George M. Weinstock, W Michael Dunne, Alex van Belkum, and Shana R Leopold
Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome"., John C Schimenti and Mary Ann Handel
HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression., Jennifer Schloss, Riyasat Ali, Jeremy Racine, Harry D Chapman, David V. Serreze, and Teresa P DiLorenzo
Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus)., C A Schmitt, S K Service, A J Jasinska, T D Dyer, M J Jorgensen, R M Cantor, George M. Weinstock, J Blangero, J R Kaplan, and N B Freimer
Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis., Manju Sharma and Robert E Braun
Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning., Susan M Sheehan and Ron Korstanje
Cre Driver Mice Targeting Macrophages., Jiayuan Shi, Li Hua, Danielle Harmer, Peishan Li, and Guangwen Ren
T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation., Kenichi Shimada, Rebecca A Porritt, Janet L Markman, Jacqueline Gire O'Rourke, Daiko Wakita, Magali Noval Rivas, Chihiro Ogawa, Lina Kozhaya, Gislâine A Martins, Derya Unutmaz, Robert H Baloh, Timothy R Crother, Shuang Chen, and Moshe Arditi
Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size., John R Shorter, Wei Huang, Ju Youn Beak, Kunjie Hua, Daniel M. Gatti, Fernando Pardo-Manuel de Villena, Daniel Pomp, and Brian C Jensen
Role of TGF-β in Self-Peptide Regulation of Autoimmunity., Bhagirath Singh, Michael D Krawetz, Rachel M De Lima, Rinee Mukherjee, Pratibha Chaturvedi, Edwin Lee-Chan, Edward H. Leiter, and Kelly L Summers
Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases., Rajan Singh, Shehla Pervin, Se-Jin Lee, Alan Kuo, Victor Grijalva, John David, Laurent Vergnes, and Srinivasa T Reddy
Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart., Daniel A Skelly, Galen T Squiers, Michael A McLellan, Mohan T Bolisetty, Paul Robson, Nadia A Rosenthal, and Alexander R Pinto
Biallelic mutations in FDXR cause neurodegeneration associated with inflammation., Jesse Slone, Yanyan Peng, Adam Chamberlin, Belinda S. Harris, Julie Kaylor, Marie T McDonald, Monica Lemmon, Mays Antonine El-Dairi, Dmitry Tchapyjnikov, Laura A Gonzalez-Krellwitz, Elizabeth A Sellars, Allyn McConkie-Rosell, Laura G Reinholdt, and Taosheng Huang
ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrp, Valentin M Sluch, Angela Banks, Hui Li, Maura A Crowley, Vanessa Davis, Chuanxi Xiang, Junzheng Yang, John T Demirs, Joanna Vrouvlianis, Barrett Leehy, Shawn Hanks, Alexandra M Hyman, Jorge Aranda, Bo Chang, Chad E Bigelow, and Dennis S Rice
Mouse Genome Database (MGD)-2018: knowledgebase for the laboratory mouse., Cynthia Smith, Judith A. Blake, James A. Kadin, Joel E Richardson, Carol J Bult, and Mouse Genome Database Group
Nervous system., Jessica M. Snyder, Catherine E. Hagan, Brad Bolon, and C Dirk Keene
A Database Study of Visual Outcomes and Intraoperative Complications of Postvitrectomy Cataract Surgery., Mohamed Kamel Soliman, Joshua S Hardin, Fayez Jawed, Sami H Uwaydat, Mohammed F Faramawi, Colin J Chu, Yit C Yang, and Ahmed B Sallam
Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness., Ji Yun Song, Puya Aravand, Sergei Nikonov, Lanfranco Leo, Arkady Lyubarsky, Jeannette L Bennicelli, Jieyan Pan, Zhangyong Wei, Ivan Shpylchak, Pamela Herrera, Daniel J Bennett, Nicoletta Commins, Albert M Maguire, Jennifer Pham, Anneke I den Hollander, Frans P M Cremers, Robert K Koenekoop, Ronald Roepman, Patsy M. Nishina, Shangzhen Zhou, Wei Pan, Gui-Shuang Ying, Tomas S Aleman, Jimmy de Melo, Ilan McNamara, Junwei Sun, Jason Mills, and Jean Bennett
Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice., Jessica R Spengler, Anita K McElroy, Jessica R Harmon, JoAnn D Coleman-McCray, Stephen R Welch, James G. Keck, Stuart T Nichol, and Christina F Spiropoulou
Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver., Jessica R Spengler, Greg Saturday, Kerry J Lavender, Cynthia Martellaro, James G. Keck, Stuart T Nichol, Christina F Spiropoulou, Heinz Feldmann, and Joseph Prescott
Resident risks., Michelle Spoto and Julia Oh