Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver.
Document Type
Article
Publication Date
1-2018
JAX Location
Reprint Collection
JAX Source
J Infect Dis 2018 Jan; 217(1):58-63
Volume
217
Issue
1
First Page
58
Last Page
63
ISSN
1537-6613
PMID
29087482
DOI
https://doi.org/10.1093/infdis/jix562
Abstract
Both Ebola virus (EBOV) and Reston virus (RESTV) cause disease in nonhuman primates, yet only EBOV causes disease in humans. To investigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV or RESTV. Consistent with differences in disease in human infection, pronounced weight loss and markers of hepatic damage and disease were observed exclusively in EBOV-infected mice. These abnormalities were associated with significantly higher EBOV replication in the liver but not in the spleen, suggesting that in this model, efficiency of viral replication in select tissues early in infection may contribute to differences in viral pathogenicity. J Infect Dis 2018 Jan; 217(1):58-63.
Recommended Citation
Spengler J,
Saturday G,
Lavender K,
Martellaro C,
Keck JG,
Nichol S,
Spiropoulou C,
Feldmann H,
Prescott J.
Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver. J Infect Dis 2018 Jan; 217(1):58-63