Document Type
Article
Publication Date
9-25-2018
JAX Source
Sci Rep 2018 Sep 25; 8(1):14339
Volume
8
Issue
1
First Page
14339
Last Page
14339
ISSN
2045-2322
PMID
30254279
DOI
https://doi.org/10.1038/s41598-018-32579-9
Grant
EY019943,CA34196
Abstract
The knockout (KO) of the adiponectin receptor 1 (AdipoR1) gene causes retinal degeneration. Here we report that ADIPOR1 protein is primarily found in the eye and brain with little expression in other tissues. Further analysis of AdipoR1 KO mice revealed that these animals exhibit early visual system abnormalities and are depleted of RHODOPSIN prior to pronounced photoreceptor death. A KO of AdipoR1 post-development either in photoreceptors or the retinal pigment epithelium (RPE) resulted in decreased expression of retinal proteins, establishing a role for ADIPOR1 in supporting vision in adulthood. Subsequent analysis of the Mfrp
Recommended Citation
Sluch V,
Banks A,
Li H,
Crowley M,
Davis V,
Xiang C,
Yang J,
Demirs J,
Vrouvlianis J,
Leehy B,
Hanks S,
Hyman A,
Aranda J,
Chang B,
Bigelow C,
Rice D.
ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrp Sci Rep 2018 Sep 25; 8(1):14339
Comments
This open access article is licensed under a Creative Commons Attribution 4.0 International License