Animal models for evaluation of albumin-based therapeutics
Document Type
Article
Publication Date
3-2018
JAX Source
Curr Opin Chem Eng 2018 Mar; 19:68-76.
DOI
https://doi.org/10.1016/j.coche.2017.11.007
Abstract
Albumin has a long serum half-life due to its unique ability to bind the cellular neonatal Fc receptor (FcRn), which provides protection from intracellular degradation. The interaction can be capitalized to improve the efficacy of drugs by extending their serum persistence. However, species-specific binding of albumin to FcRn challenges preclinical development. The goal of this brief review is to provide insights into how FcRn and cross-species binding differences affect the pharmacokinetics of human serum albumin (HSA) in different animal models, and gives an overview of genetically modified mice that may serve as improved models for testing of albumin-based drugs. Curr Opin Chem Eng 2018 Mar; 19:68-76.
Recommended Citation
Nilsen J,
Sandlie I,
Roopenian DC,
Andersen J.
Animal models for evaluation of albumin-based therapeutics Curr Opin Chem Eng 2018 Mar; 19:68-76.