Document Type
Article
Publication Date
2-6-2018
JAX Source
Cell Rep 2018 Feb 6; 22(6):1392-1400
Volume
22
Issue
6
First Page
1392
Last Page
1400
ISSN
2211-1247
PMID
29425496
DOI
https://doi.org/10.1016/j.celrep.2018.01.035
Abstract
Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy. Cell Rep 2018 Feb 6; 22(6):1392-1400
Recommended Citation
Munshi M,
Gardin J,
Singh A,
Luberto C,
Rieger R,
Bouklas T,
Fries B,
Del Poeta M.
The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans. Cell Rep 2018 Feb 6; 22(6):1392-1400
Comments
Open access Under a Creative Commons license.