Document Type
Article
Publication Date
1-30-2018
JAX Source
Cell Rep Jan 30; 22(5):1301-1312
Volume
22
Issue
5
First Page
1301
Last Page
1312
ISSN
2211-1247
PMID
29386116
DOI
https://doi.org/10.1016/j.celrep.2018.01.006
Abstract
Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a common symptom. Here, we demonstrate that the onset of cold hypersensitivity precedes tactile allodynia in a model of partial nerve injury, and this temporal divergence was associated with major differences in global gene expression in innervating dorsal root ganglia. Transcripts whose expression change correlates with the onset of cold allodynia were nociceptor related, whereas those correlating with tactile hypersensitivity were immune cell centric. Ablation of TrpV1 lineage nociceptors resulted in mice that did not acquire cold allodynia but developed normal tactile hypersensitivity, whereas depletion of macrophages or T cells reduced neuropathic tactile allodynia but not cold hypersensitivity. We conclude that neuropathic pain incorporates reactive processes of sensory neurons and immune cells, each leading to distinct forms of hypersensitivity, potentially allowing drug development targeted to each pain type. Cell Rep Jan 30; 22(5):1301-1312.
Recommended Citation
Cobos E,
Nickerson C,
Gao F,
Chandran V,
Bravo-Caparrós I,
González-Cano R,
Riva P,
Andrews N,
Latremoliere A,
Seehus C,
Perazzoli G,
Nieto F,
Joller N,
Painter M,
Ma C,
Omura T,
Chesler E,
Geschwind D,
Coppola G,
Rangachari M,
Woolf C,
Costigan M.
Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling. Cell Rep Jan 30; 22(5):1301-1312
Comments
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