Genomic Profiling of Two Histologically Distinct Rare Urothelial Cancers in a Clinical Setting to Identify Potential Therapeutic Options for Treatment and Management of Disease.

Authors

Andrew N Hesse, The Jackson LaboratoryFollow
William Fabricius
Christian A Thomas
Ramesh Gaindh
Robert Christman
Pavalan Selvam, The Jackson LaboratoryFollow
Matthew Prego, The Jackson LaboratoryFollow
Gregory Lewis, The Jackson LaboratoryFollow
Jasmina Uvalic, The Jackson LaboratoryFollow
Daniel Bergeron, The Jackson LaboratoryFollow
Shelbi Burns, The Jackson LaboratoryFollow
Bridgette Sisson, The Jackson LaboratoryFollow
Kevin Kelly, The Jackson LaboratoryFollow
Jens Rueter, The Jackson LaboratoryFollow
Honey V Reddi, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

4-23-2018

JAX Source

Case Rep Oncol 2018 Mar 27; 11(1):196-205.

Volume

11

Issue

1

First Page

196

Last Page

205

ISSN

1662-6575

PMID

29681821

DOI

https://doi.org/10.1159/000487882

Grant

Harold Alfond Foundation, Maine Cancer Genetics Initiative

Abstract

Molecular profiling of urothelial cancers for therapeutic and prognostic potential has been very limited due to the absence of cancer-specific targeted therapies. We describe here 2 clinical cases with a histological diagnosis of an invasive sarcomatoid and a poorly differentiated carcinoma favoring urothelial with some neuroendocrine differentiation, two of the rarer types of urothelial cancers, which were evaluated for mutations in 212 genes for single-nucleotide variants and copy-number variants and 53 genes for fusions associated with solid tumors. In both cases, we identified variants in 2 genes, Case Rep Oncol 2018 Mar 27; 11(1):196-205.

Comments

This open access article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)

Recommended Citation

Hesse A, Fabricius W, Thomas C, Gaindh R, Christman R, Selvam P, Prego M, Lewis G, Uvalic J, Bergeron D, Burns S, Sisson B, Kelly K, Rueter J, Reddi H. Genomic Profiling of Two Histologically Distinct Rare Urothelial Cancers in a Clinical Setting to Identify Potential Therapeutic Options for Treatment and Management of Disease. Case Rep Oncol 2018 Mar 27; 11(1):196-205.