Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults.
Document Type
Article
Publication Date
8-2018
JAX Source
Neurol Clin 2018 Aug; 36(3):421-437
Volume
36
Issue
3
First Page
421
Last Page
437
ISSN
1557-9875
PMID
30072063
DOI
https://doi.org/10.1016/j.ncl.2018.04.002
Grant
CA190121
Abstract
Recent advances in molecular analysis and genome sequencing have prompted a paradigm shift in neuropathology. This article discusses the discovery and clinical relevance of molecular biomarkers in diffuse gliomas in adults and how these biomarkers led to revision of the World Health Organization classification of these tumors. We relate progress in clinical classification to an overview of studies using molecular profiling to study gene expression and DNA methylation to categorize diffuse gliomas in adults and issues dealing with intratumoral heterogeneity. These efforts will refine the taxonomy of diffuse gliomas, facilitate selection of appropriate treatment regimens, and ultimately improve patient's lives.
Recommended Citation
Barthel F,
Johnson K,
Wesseling P,
Verhaak R.
Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults. Neurol Clin 2018 Aug; 36(3):421-437
Comments
The authors thank members of the Verhaak laboratory for insightful discussion and valuable input. The authors thank Zoe¨ Reifsnyder of the Jackson Laboratory creative team for artwork.