Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults.

Authors

Floris P Barthel, The Jackson LaboratoryFollow
Kevin C Johnson, The Jackson LaboratoryFollow
Pieter Wesseling
Roel G W Verhaak, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

8-2018

JAX Source

Neurol Clin 2018 Aug; 36(3):421-437

Volume

36

Issue

3

First Page

421

Last Page

437

ISSN

1557-9875

PMID

30072063

DOI

https://doi.org/10.1016/j.ncl.2018.04.002

Grant

CA190121

Abstract

Recent advances in molecular analysis and genome sequencing have prompted a paradigm shift in neuropathology. This article discusses the discovery and clinical relevance of molecular biomarkers in diffuse gliomas in adults and how these biomarkers led to revision of the World Health Organization classification of these tumors. We relate progress in clinical classification to an overview of studies using molecular profiling to study gene expression and DNA methylation to categorize diffuse gliomas in adults and issues dealing with intratumoral heterogeneity. These efforts will refine the taxonomy of diffuse gliomas, facilitate selection of appropriate treatment regimens, and ultimately improve patient's lives.

Comments

The authors thank members of the Verhaak laboratory for insightful discussion and valuable input. The authors thank Zoe¨ Reifsnyder of the Jackson Laboratory creative team for artwork.

Recommended Citation

Barthel F, Johnson K, Wesseling P, Verhaak R. Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults. Neurol Clin 2018 Aug; 36(3):421-437