Document Type
Article
Publication Date
11-9-2018
JAX Source
Sci Rep 2018 Nov 9; 8(1):16607
Volume
8
Issue
1
First Page
16607
Last Page
16607
ISSN
2045-2322
PMID
30413788
DOI
https://doi.org/10.1038/s41598-018-35126-8
Abstract
Chronic periodontitis (CP) is a microbial dysbiotic disease linked to increased risk of oral squamous cell carcinomas (OSCCs). To address the underlying mechanisms, mouse and human cell infection models and human biopsy samples were employed. We show that the 'keystone' pathogen Porphyromonas gingivalis, disrupts immune surveillance by generating myeloid-derived dendritic suppressor cells (MDDSCs) from monocytes. MDDSCs inhibit CTLs and induce FOXP3 + T
Recommended Citation
Arjunan P,
Meghil M,
Pi W,
Xu J,
Lang L,
El-Awady A,
Sullivan W,
Rajendran M,
Rabelo M,
Wang T,
Tawfik O,
Kunde-Ramamoorthy G,
Singh N,
Muthusamy T,
Susin C,
Teng Y,
Arce R,
Cutler C.
Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation. Sci Rep 2018 Nov 9; 8(1):16607
Comments
This open access article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)