Document Type

Article

Publication Date

1-4-2018

JAX Source

Nucleic Acids Res 2018 Jan 4; 46(D1):D843-D850

Volume

46

Issue

D1

First Page

843

Last Page

843

ISSN

1362-4962

PMID

29136208

DOI

https://doi.org/10.1093/nar/gkx1082

Grant

DA028420, DA045401, AG022308

Abstract

The Mouse Phenome Database (MPD; https://phenome.jax.org) is a widely used resource that provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD houses individual animal data with detailed, searchable protocols, and makes these data available to other resources via API. MPD provides rigorous curation of experimental data and supporting documentation using relevant ontologies and controlled vocabularies. Most data in MPD are from inbreds and other reproducible strains such that the data are cumulative over time and across laboratories. The resource has been expanded to include the QTL Archive and other primary phenotype data from mapping crosses as well as advanced high-diversity mouse populations including the Collaborative Cross and Diversity Outbred mice. Furthermore, MPD provides a means of assessing replicability and reproducibility across experimental conditions and protocols, benchmarking assays in users' own laboratories, identifying sensitized backgrounds for making new mouse models with genome editing technologies, analyzing trait co-inheritance, finding the common genetic basis for multiple traits and assessing sex differences and sex-by-genotype interactions. Nucleic Acids Res 2018 Jan 4; 46(D1):D843-D850.

Comments

This is an open access article distributed under the terms of the Creative Commons CC BY license.

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