Document Type

Article

Publication Date

1-1-2018

JAX Source

Front Immunol 2018 Sep 27;9:2169

PMID

30319629

DOI

https://doi.org/10.3389/fimmu.2018.02169

Grant

AI133440,AI135221

Abstract

T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells that collaborate with B cells to promote and regulate humoral responses. Unlike other CD4+ effector lineages, Tfh cells require interactions with both dendritic cells (DCs) and B cells to complete their differentiation. While numerous studies have assessed the potential of different DC subsets to support Tfh priming, the conclusions of these studies depend heavily on the model and method of immunization used. We propose that the location of different DC subsets within the lymph node (LN) and their access to antigen determine their potency in Tfh priming. Finally, we provide a three-step model that accounts for the ability of multiple DC subsets and related lineages to support the Tfh differentiation program.

Comments

We would like to thank Matt Wimsatt for generating figures, and Iiro Taneli Helenius for critical review of the manuscript.

Open access under the terms of the Creative Commons Attribution License (CC BY)

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